Department of Mathematics and Statistics, Georgia State University, USA.
Stat Med. 2009 Dec 20;28(29):3611-25. doi: 10.1002/sim.3709.
In a genetic epidemiology study of a trait, prior to collecting genotype data the foremost task is to test for familial aggregation and examine heritability. Recently, functional traits have drawn attentions from investigators. Here, to test for familial aggregation of a functional trait in the family studies, a test constructed based on the leading functional principal component of heritability, which is a summary measure of temporal genetic variation in a functional trait, is proposed. The p-value of the test can be approximated by a permutation procedure given the family structure. The asymptotic distribution of the test statistic is derived. Simulations are carried out to examine the size and the power of the test. The proposed methods are applied to the total cholesterol data in the Framingham Heart Study.
在一项关于特征的遗传流行病学研究中，在收集基因型数据之前，首要任务是检验家族聚集性并检查遗传性。最近，功能特征引起了研究人员的关注。在这里，为了在家族研究中检验功能特征的家族聚集性，提出了一种基于遗传性主导功能主成分的检验方法，该方法是功能特征时间遗传变异的综合度量。根据家族结构，可以通过置换程序来近似检验的 p 值。推导了检验统计量的渐近分布。进行了模拟以检验检验的大小和功效。所提出的方法应用于弗雷明汉心脏研究中的总胆固醇数据。
