Highly selective and sensitive heparin probing from supramolecular assembly of pyrene derivatives.
作者信息
Zeng Lintao, Wang Pengfei, Zhang Hongyan, Zhuang Xiaoqing, Dai Qing, Liu Weimin
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
出版信息
Org Lett. 2009 Oct 1;11(19):4294-7. doi: 10.1021/ol901392p.
PMID:19731922
Abstract
A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for heparin over other biological molecules. Upon binding with heparin, PQ shows a typical excimer emission peaked at 489 nm along with a weak monomer emission at 376 nm. Moreover, PQ also shows good performance to detect the heparin in serum.
摘要
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