Department of Biomedical & Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, 121 Link Hall, Syracuse, NY 13244, USA.
Expert Opin Ther Pat. 2009 Nov;19(11):1581-601. doi: 10.1517/13543770903222293.
Quorum sensing (QS) is a microbial cell-cell signaling system that correlates gene expression with cell population density. It plays important roles in intra-species communications and is also involved in inter-species and microbe-host interactions. Because QS controls a wide spectrum of phenotypes including virulence and biofilm formation, inhibition of QS may provide alternative therapeutic methods for treating microbial infections.
To provide an overview of QS inhibitors and their applications.
Search of databases for patents on QS inhibition submitted between 1999 and 2008.
RESULTS/CONCLUSIONS: The reported QS inhibitors include both natural and synthetic agents and can be mainly categorized in three classes: nonpeptide small molecules, peptides and proteins. These inhibitors interrupt QS by repressing signal generation, blocking signal receptors or disrupting QS signals, and provide an alternative approach to controlling microbial pathogenesis.
群体感应（QS）是一种微生物细胞-细胞信号转导系统，它将基因表达与细胞群体密度相关联。它在种内通讯中起着重要作用，也参与种间和微生物-宿主相互作用。由于 QS 控制着包括毒力和生物膜形成在内的广泛表型，因此抑制 QS 可能为治疗微生物感染提供了替代的治疗方法。
概述 QS 抑制剂及其应用。
检索 1999 年至 2008 年间提交的 QS 抑制专利的数据库。
结果/结论：报道的 QS 抑制剂包括天然和合成制剂，可主要分为三类：非肽小分子、肽和蛋白质。这些抑制剂通过抑制信号生成、阻断信号受体或破坏 QS 信号来中断 QS，为控制微生物发病机制提供了一种替代方法。
