Kao Godinez Ana Karina, Villicaña Claudia, Basilio Heredia José, Valdez-Torres José Benigno, Muy-Rangel Maria, León-Félix Josefina
Centro de Investigación y Desarrollo, A.C., Culiacán 80110, Sinaloa, Mexico.
SECIHTI-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán 80110, Sinaloa, Mexico.
Molecules. 2025 Apr 9;30(8):1682. doi: 10.3390/molecules30081682.
Food safety is a significant global and local concern due to the threat of foodborne pathogens to public health and food security. Bacterial biofilms are communities of bacteria adhered to surfaces and represent a persistent contamination source in food environments. Their resistance to conventional antimicrobials exacerbates the challenge of eradication, driving the search for alternative strategies to control biofilms. Unconventional or "green" antimicrobial agents have emerged as promising solutions due to their sustainability and effectiveness. These agents include bacteriophages, phage-derived enzymes, plant extracts, and combinations of natural antimicrobials, which offer novel mechanisms for targeting biofilms. This approach aligns with the "One Health" concept, which underscores the interconnectedness of human, animal, and environmental health and advocates for integrated strategies to address public health challenges. Employing unconventional antimicrobial agents to manage bacterial biofilms can enhance food safety, protect public health, and reduce environmental impacts by decreasing reliance on conventional antimicrobials and mitigating antimicrobial resistance. This review explores the use of unconventional antimicrobials to combat foodborne pathogen biofilms, highlighting their mechanisms of action, antibiofilm activities, and the challenges associated with their application in food safety. By addressing these issues from a "One Health" perspective, we aim to demonstrate how such strategies can promote sustainable food safety, improve public health outcomes, and support environmental health, ultimately fostering a more integrated approach to combating foodborne pathogen biofilms.
由于食源性病原体对公众健康和粮食安全构成威胁，食品安全是一个重大的全球和地方关注问题。细菌生物膜是附着在表面的细菌群落，是食品环境中持续存在的污染源。它们对传统抗菌剂的抗性加剧了根除的挑战，促使人们寻找控制生物膜的替代策略。非传统或 “绿色” 抗菌剂因其可持续性和有效性而成为有前景的解决方案。这些制剂包括噬菌体、噬菌体衍生酶、植物提取物以及天然抗菌剂的组合，它们为靶向生物膜提供了新机制。这种方法与 “同一健康” 概念相一致，该概念强调人类、动物和环境健康的相互联系，并倡导采用综合策略来应对公共卫生挑战。使用非传统抗菌剂来管理细菌生物膜可以通过减少对传统抗菌剂的依赖和减轻抗菌药物耐药性来提高食品安全、保护公众健康并减少对环境的影响。本综述探讨了使用非传统抗菌剂对抗食源性病原体生物膜的情况，重点介绍了它们的作用机制、抗生物膜活性以及在食品安全应用中相关的挑战。通过从 “同一健康” 的角度解决这些问题，我们旨在展示这些策略如何促进可持续食品安全、改善公共卫生结果并支持环境卫生，最终促进采用更综合的方法来对抗食源性病原体生物膜。
