Alm El-Din Mohamed A, Taghian Alphonse G
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Semin Radiat Oncol. 2009 Oct;19(4):229-35. doi: 10.1016/j.semradonc.2009.05.005.
Neoadjuvant chemotherapy achieves high response rates in patients with breast cancer and has been used to reduce tumor size and allow for breast conservation in individuals who initially required mastectomy. The goals of this approach are to achieve optimal locoregional control together with acceptable cosmesis. In the setting of locally advanced disease, breast preservation appears to be feasible for appropriately selected patients whose tumors show adequate downstaging in response to induction chemotherapy. Nevertheless, further prospective randomized trials are warranted to better evaluate the results of this approach as compared with mastectomy.
新辅助化疗在乳腺癌患者中可实现高缓解率，并已用于缩小肿瘤大小，使最初需要乳房切除术的患者能够保留乳房。这种方法的目标是实现最佳的局部区域控制以及可接受的美容效果。在局部晚期疾病的情况下，对于经诱导化疗后肿瘤显示出足够降期的适当选择的患者，保乳似乎是可行的。然而，与乳房切除术相比，仍需要进一步的前瞻性随机试验来更好地评估这种方法的效果。
