Breen Matthew
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, and Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC 27606, USA.
Top Companion Anim Med. 2009 Aug;24(3):113-21. doi: 10.1053/j.tcam.2009.03.002.
The release of an annotated human genome sequence assembly and the emergence of genomics technologies have led to significant advances in our understanding of many human diseases including cancers. As DNA sequencing technology has become less costly, the field of comparative genomics has progressed rapidly and attention has turned now to generating whole genome assemblies and dedicated genomics resources for veterinary species. Such progress brings a whole new series of opportunities to advance veterinary medicine. Many human and animal diseases share a pathogenetic basis, and although veterinary species need advances in biomedical research in their own right, the consideration of companion animals also as good comparative models for human disease saw the emergence of the "one medicine" concept. The future of many areas of human and veterinary biomedical research is very much interdependent, with one of the closest associations being in oncology. It is inevitable that veterinary oncology will benefit enormously from data derived from genomics and that this era will see a huge shift in the ways in which companion animal cancer patients are evaluated and subsequently treated. Here, we will review some of the advancements of genomics as they relate to veterinary oncology.
带注释的人类基因组序列组装的发布以及基因组学技术的出现，使我们对包括癌症在内的许多人类疾病的理解取得了重大进展。随着DNA测序技术成本降低，比较基因组学领域迅速发展，现在人们的注意力已转向为兽医物种生成全基因组组装和专用基因组学资源。这一进展为推进兽医学带来了全新的一系列机遇。许多人类和动物疾病具有共同的发病机制，尽管兽医物种自身就需要生物医学研究取得进展，但将伴侣动物也视为人类疾病的良好比较模型促使了 “同一医学” 概念的出现。人类和兽医生物医学研究的许多领域的未来在很大程度上相互依存，其中最密切的关联之一在于肿瘤学。兽医肿瘤学必然会从基因组学数据中极大受益，并且在这个时代，伴侣动物癌症患者的评估和后续治疗方式将发生巨大转变。在此，我们将回顾一些与兽医肿瘤学相关的基因组学进展。
