Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, SV-AI Extension, Station 15, 1015 Lausanne, Switzerland.
Mol Aspects Med. 2009 Dec;30(6):406-12. doi: 10.1016/j.mam.2009.08.007. Epub 2009 Sep 2.
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.
炭疽毒素-受体相互作用对毒素递送至宿主细胞质至关重要。这篇综述总结了关于保护性抗原（PA）毒素亚基与 ANTXR1 和 ANTXR2 细胞受体相互作用的分子细节，以及受体类型如何决定 PA 孔形成的低 pH 阈值，还讨论了细胞因子在调节毒素-受体复合物内吞作用中的作用。
