Escola de Veterinária, Universidade Federal de Minas Gerais. Av. Antônio Carlos, 6627, 30123-970 Belo Horizonte, MG, Brazil.
Vet J. 2010 May;184(2):146-55. doi: 10.1016/j.tvjl.2009.04.010. Epub 2009 Sep 3.
Bovine brucellosis is one of the most important zoonotic diseases worldwide, and is of particular significance in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of the genus Brucella. Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows, and fibrinous pleuritis with interstitial pneumonia in aborted fetuses and newborn calves. This article considers the pathogenesis of Brucella abortus and reviews the ability of the pathogen to invade phagocytic and non-phagocytic host cells, resist the acidified intraphagosomal environment, and inhibit phagosome-lysosome fusion. Significant aspects of innate and adaptive immunity against brucellosis are also discussed.
牛布鲁氏菌病是全球最重要的人畜共患病之一，在发展中国家尤为重要。该病由布鲁氏菌属革兰氏阴性球杆菌引起，可导致妊娠牛晚期流产、死胎和弱仔，造成严重的经济损失。病变包括怀孕母牛的坏死性胎盘炎和间质性乳腺炎，流产胎儿和新生小牛的纤维素性胸膜炎和间质性肺炎。本文考虑了流产布鲁氏菌的发病机制，并回顾了病原体入侵吞噬细胞和非吞噬宿主细胞、抵抗酸化的吞噬体内环境以及抑制吞噬体-溶酶体融合的能力。还讨论了针对布鲁氏菌病的固有和适应性免疫的重要方面。
