联合使用胎儿纤连蛋白和宫颈长度预测无症状双胎妊娠的自发性早产
Prediction of spontaneous preterm birth in asymptomatic twin pregnancies with the use of combined fetal fibronectin and cervical length.
作者信息
Fox Nathan S, Saltzman Daniel H, Klauser Chad K, Peress Danielle, Gutierrez Christina V, Rebarber Andrei
机构信息
Maternal Fetal Medicine Associates, PLLC, New York, NY 10128, USA.
出版信息
Am J Obstet Gynecol. 2009 Sep;201(3):313.e1-5. doi: 10.1016/j.ajog.2009.06.018.
OBJECTIVE
The purpose of this study was to evaluate combined fetal fibronectin (fFN) test result and cervical length (CL) as predictors of spontaneous preterm birth in asymptomatic twin pregnancies.
STUDY DESIGN
We examined a retrospective cohort of 155 twin pregnancies with combined fFN and CL testing between 22 and 32 weeks gestation.
RESULTS
A positive fFN test result at 22-32 weeks or a CL <20 mm increased the risk of spontaneous preterm birth at <37, <34, <32, <30, and <28 weeks' gestation. The combination of a positive fFN test result and CL<20 mm had a significantly higher positive predictive value for delivery at all gestational ages than either positive test alone. On adjusted analysis, a positive fFN test result was a stronger predictor of spontaneous preterm birth than a short CL.
CONCLUSION
In asymptomatic twin pregnancies, fFN and CL testing between 22 and 32 weeks gestation can identify pregnancies that are at significantly increased risk for preterm birth, including deliveries at <28 weeks' gestation.
目的
本研究旨在评估联合检测胎儿纤连蛋白（fFN）结果和宫颈长度（CL）作为无症状双胎妊娠自发性早产预测指标的价值。
研究设计
我们对155例双胎妊娠进行了回顾性队列研究，这些孕妇在妊娠22至32周期间接受了fFN和CL联合检测。
结果
妊娠22 - 32周时fFN检测结果为阳性或CL<20 mm会增加妊娠<37周、<34周、<32周、<30周和<28周时自发性早产的风险。fFN检测结果为阳性且CL<20 mm的联合情况，在所有孕周对于分娩的阳性预测值均显著高于单独任何一项阳性检测结果。经校正分析，fFN检测结果为阳性比CL短是自发性早产更强的预测指标。
结论
在无症状双胎妊娠中，妊娠22至32周期间进行fFN和CL检测可识别早产风险显著增加的妊娠，包括妊娠<28周时的分娩。
Zotero 插件