Charleston Alcohol Research Center, Center for Drug and Alcohol Programs, Medical University of South Carolina, South Carolina, USA.
Addict Behav. 2010 Jan;35(1):42-5. doi: 10.1016/j.addbeh.2009.07.002. Epub 2009 Aug 7.
The present study sought to address a gap in the literature by providing preliminary evidence of the prevalence and clinical characteristics of comorbid generalized anxiety disorder (GAD) and alcohol use disorders (AUD) in a front-line outpatient substance abuse clinic. Of 39 outpatients meeting criteria for an AUD, nearly half (46%) also met criteria for current GAD. The onset of GAD occurred prior to AUD in 67% of comorbid cases, with an average time lag of 12.5 years among individuals with primary GAD. Participants with comorbid GAD-AUD endorsed higher levels of worry severity and worry-reduction alcohol expectancies, and 55.6% of comorbid participants had a history of suicide attempts. Groups did not differ on anxiety sensitivity, social anxiety, or depression. Comorbid participants were more likely to indicate that worry interfered with their substance abuse treatment, and to indicate interest in concurrent treatment targeting their worry. Study findings provide initial evidence that GAD may be a prevalent and relevant factor among individuals with AUD seeking outpatient substance abuse treatment.
本研究旨在填补文献空白,初步探讨一线门诊药物滥用诊所中广泛性焦虑障碍(GAD)和酒精使用障碍(AUD)共病的患病率和临床特征。在符合 AUD 标准的 39 名门诊患者中,近一半(46%)也符合当前 GAD 的标准。在共病病例中,67%的 GAD 先于 AUD 发生,原发性 GAD 患者的平均时间间隔为 12.5 年。共病 GAD-AUD 的参与者表示担忧严重程度和减少担忧的酒精预期更高,55.6%的共病参与者有自杀未遂史。两组在焦虑敏感、社交焦虑或抑郁方面没有差异。共病参与者更有可能表示担忧会干扰他们的药物滥用治疗,并表示有兴趣同时接受针对他们担忧的治疗。研究结果初步表明,在寻求门诊药物滥用治疗的 AUD 患者中,GAD 可能是一种普遍存在且相关的因素。