Coelho J, Soyer P, Pautrat K, Boudiaf M, Vahedi K, Reignier S, Valleur P, Marteau P
Département médicochirurgical de pathologie digestive, hôpital Lariboisière, 2 rue Ambroise-Paré, Paris, France.
Gastroenterol Clin Biol. 2009 Oct;33(10-11 Suppl):F75-81. doi: 10.1016/j.gcb.2009.07.024. Epub 2009 Sep 4.
Stenosis is the most frequent complication during Crohn's disease. The lesion can be inflammatory, or due to a fibrosing or neoplastic process. The medical treatment with anti-inflammatory drugs is usually sufficient as first line treatment; fibrous lesions require endoscopic or surgical procedures while neoplastic lesions require surgery. A multidisciplinary approach (radiologic, medical, surgical and endoscopic) is needed. In a first part, we discuss the definition of stenosis and the modalities of imaging (particularly MRI) and of treatment (particularly with TNFalpha antagonists). Then we expose the strategy for the management of the most frequent clinical situations: occlusion, ileal inflammatory stenosis, stenosis of an ileocolonic anastomosis and chronic fibrous stenosis. The treatment decision takes into account the results of radiological assessment, CRP level and the effects of the previous treatments.
狭窄是克罗恩病最常见的并发症。病变可能是炎症性的,或是由纤维化或肿瘤性病变引起。抗炎药物的药物治疗通常作为一线治疗已足够;纤维性病变需要内镜或手术治疗,而肿瘤性病变则需要手术治疗。需要多学科方法(放射学、医学、外科和内镜)。在第一部分,我们讨论狭窄的定义、成像方式(特别是磁共振成像)和治疗方式(特别是使用肿瘤坏死因子α拮抗剂)。然后我们阐述了处理最常见临床情况的策略:梗阻、回肠炎性狭窄、回结肠吻合口狭窄和慢性纤维性狭窄。治疗决策要考虑放射学评估结果、C反应蛋白水平和先前治疗的效果。