Monpoux F, Deville A, Philip P J, Baudoin F, Sudaka I, Bourrier T, Cottalorda J, Armengaud F, Mariani R
Clinique Médicale Infantile, du Laboratoire Central d'Hématologie, Hôpital de Cimiez, Nice.
Arch Fr Pediatr. 1990 May;47(5):335-7.
The outcome of infants born to HIV1 seropositive (HIV1+) mothers is still uncertain is spite of current progress in techniques for viral detection. Using the almost elective tropism of HIV1 virus for CD4 lymphocytes and the central role of these cells in the immune regulation, we studied blood lymphocyte populations with 7 monoclonal antibodies during the first month of life in 28 newborns of HIV1 seropositive mothers. Our data are compared to an age-matched population of 35 control infants. According to our results, the coexistence of a low CD8 lymphocyte percentage together with a high CD4/CD8 ratio seems to be correlated with an unfavourable outcome.
尽管目前病毒检测技术取得了进展，但HIV1血清阳性（HIV1+）母亲所生婴儿的结局仍不确定。利用HIV1病毒对CD4淋巴细胞的几乎选择性嗜性以及这些细胞在免疫调节中的核心作用，我们在28名HIV1血清阳性母亲的新生儿出生后的第一个月，用7种单克隆抗体研究了血液淋巴细胞群体。我们的数据与35名年龄匹配的对照婴儿群体进行了比较。根据我们的结果，低CD8淋巴细胞百分比与高CD4/CD8比值并存似乎与不良结局相关。
