Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada.
Neuropsychologia. 2010 Jan;48(1):156-64. doi: 10.1016/j.neuropsychologia.2009.08.023.
The neural correlates of recollection were examined using event-related functional MRI. We examined how the presence of different visual context information during encoding of target words influenced later recollection for the words presented alone at retrieval. Participants studied words presented with different pictures of faces or scrambled faces on each trial, and on a subsequent scanned recognition test made 'remember', 'know' or 'new' responses to words presented alone. Prior to the study phase, participants performed a localizer task, in which the fusiform face area (FFA) was identified. We compared brain activation patterns for remember and know responses given to words studied with faces as compared to scrambled faces. Though behaviourally participants showed no difference in memory performance depending on encoding trial type, both a group- and individual-based region-of-interest analysis showed increased activation in the functionally-defined FFA for remember responses given to words studied with faces compared to scrambled faces. A regression analysis additionally showed that activation in the right fusiform gyrus increased as the relative recollection benefit for words studied with meaningful (face) compared to non-meaningful (scrambled face) context information increased. Results suggest that context-specific brain regions implicated during encoding are recruited during retrieval, and that the degree to which participants activate context-specific brain regions during retrieval is related to a behavioural benefit in later recollection for target information presented alone.
使用事件相关功能磁共振成像研究了回忆的神经相关性。我们研究了在目标词编码过程中呈现不同视觉上下文信息时如何影响随后在检索中单独呈现这些词的回忆。参与者在每次试验中都学习了带有不同面孔或乱序面孔的单词，然后在随后的扫描识别测试中对单独呈现的单词做出“记得”、“知道”或“新”的反应。在研究阶段之前，参与者进行了一个局部器任务，在此任务中确定了梭状回面孔区（FFA）。我们比较了对带有面孔的单词和乱序面孔的单词进行回忆和知道反应时的大脑激活模式。尽管参与者在记忆表现上没有因编码试验类型而异，但基于组和个体的感兴趣区域分析都显示，与带有乱序面孔的单词相比，对带有面孔的单词进行回忆时，功能定义的 FFA 中的激活增加。回归分析还表明，当带有有意义（面孔）的上下文信息的单词与无意义（乱序面孔）的上下文信息相比，回忆的相对优势增加时，右侧梭状回回的激活增加。结果表明，在编码过程中涉及的特定于上下文的大脑区域在检索时被招募，并且参与者在检索过程中激活特定于上下文的大脑区域的程度与目标信息单独呈现时的行为益处有关。
