Farr P M, Diffey B L, Matthews J N
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1990 Jun;122(6):809-15. doi: 10.1111/j.1365-2133.1990.tb06270.x.
The effect of terfenadine on the response to irradiation with blue light was measured in seven patients with erythropoietic protoporphyria. Terfenadine caused significant inhibition of the immediate flare reaction, but did not alter the erythemal response localized to the irradiation sites. Treatment with beta-carotene had no effect on the flare and erythemal responses. However, the flare reaction was still inhibited by terfenadine during treatment with beta-carotene. These results show that histamine release is involved in the mechanism of porphyrin photosensitivity. H1 receptor antagonists may be of use in the treatment of patients with erythropoietic protoporphyria.
在7例红细胞生成性原卟啉病患者中测定了特非那定对蓝光照射反应的影响。特非那定可显著抑制即刻红斑反应，但不改变照射部位局限的红斑反应。β-胡萝卜素治疗对红斑和红斑反应无影响。然而，在β-胡萝卜素治疗期间，特非那定仍可抑制红斑反应。这些结果表明组胺释放参与了卟啉光敏反应的机制。H1受体拮抗剂可能对红细胞生成性原卟啉病患者的治疗有用。
