Department of Diagnostic Radiology and Organ Imaging, United Christian Hospital, Hong Kong, China.
Urol Oncol. 2011 May-Jun;29(3):275-9. doi: 10.1016/j.urolonc.2009.05.007. Epub 2009 Sep 6.
A number of large-scaled studies done in Western countries have proven a positive relationship between serum prostate-specific antigen (PSA) level and prevalence of positive bone scan findings in newly diagnosed prostate cancer (CaP) patients. The objective of this study is to verify that the tendency occurs as well in Asian population, as well as to establish a possible correlation between PSA level, bone scan result, and Gleason score.
Records of 116 patients diagnosed to have CaP were reviewed retrospectively for bone scan results, PSA levels, and Gleason score.
Thirty-four patients were proven to have bone metastases based on positive bone scintigraphy result. None of these patients had a PSA level of less than 10 ng/ml. Two patients had PSA level between 11 and 20, and 15 patients had PSA level between 21 and 200. For patients with PSA level over 201, 17 had bone metastases on bone scintigraphy.
Based on the PSA level, the likelihood of positive bone scintigraphy result can be postulated. According to PSA levels, staging investigations can be more selective for patients with confirmed CaP. The risk of having positive bone scan is so low that it is not required for patients with PSA level less than 10 ng/ml. On the other hand, on studying the correlation between Gleason score and PSA level or bone scan results, no statistically significant relationship was established.
一些在西方国家进行的大规模研究已经证明，在新诊断的前列腺癌（CaP）患者中，血清前列腺特异性抗原（PSA）水平与骨扫描阳性结果之间存在正相关关系。本研究的目的是验证这种趋势是否也存在于亚洲人群中，并确定 PSA 水平、骨扫描结果和 Gleason 评分之间的可能相关性。
回顾性分析了 116 例诊断为 CaP 的患者的骨扫描结果、PSA 水平和 Gleason 评分记录。
34 例患者经骨闪烁扫描证实有骨转移。这些患者的 PSA 水平均低于 10ng/ml。2 例患者的 PSA 水平在 11-20ng/ml 之间，15 例患者的 PSA 水平在 21-200ng/ml 之间。对于 PSA 水平超过 201ng/ml 的患者，17 例在骨扫描上有骨转移。
根据 PSA 水平，可以推测出骨闪烁扫描阳性结果的可能性。根据 PSA 水平，可以对确诊的 CaP 患者进行更有选择性的分期检查。PSA 水平低于 10ng/ml 的患者发生骨扫描阳性的风险很低，因此不需要进行骨扫描。另一方面，在研究 Gleason 评分与 PSA 水平或骨扫描结果之间的相关性时，没有建立统计学上的显著关系。
