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前列腺组织中JPX和LINC00641非编码RNA的表达：一项病例对照研究。

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study.

作者信息

Sajjadi Roshanak S, Modarressi Mohammad Hossein, Tabatabaiefar Mohammad Amin

机构信息

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.

出版信息

Res Pharm Sci. 2021 Aug 19;16(5):493-504. doi: 10.4103/1735-5362.323916. eCollection 2021 Oct.

DOI:10.4103/1735-5362.323916
PMID:34522197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8407155/
Abstract

BACKGROUND AND PURPOSE

Prostate cancer (PC) is the second most prevalent cancer in men. Prostate-specific antigen (PSA) is the main biomarker for screening PC. An increase in PSA could lead to false-positive results. Thus, more appropriate markers should be investigated. In the present study, JPX and LINC00641 expression levels were measured in tumoral prostate tissue compared with the non-tumor tissue.

EXPERIMENTAL APPROACH

43 pairs of prostate tumoral and non-tumor tissue were prepared. The expression levels of JPX and LINC00641 were investigated by RT-qPCR.

FINDINGS/RESULTS: Significant upregulation of LINC00641 (2.47 ± 0.5 1.41 ± 0.2) and downregulation of JPX (1.42 ± 0.6 2.83 ± 1.0) were observed in PC tissues compared with the normal tissues (their adjacent non-tumoral tissues).

CONCLUSION AND IMPLICATIONS

Dysregulation of JPX and LINC00641 in PC patients could be used in the future as a prognostic biomarker in PC.

摘要

背景与目的

前列腺癌（PC）是男性中第二常见的癌症。前列腺特异性抗原（PSA）是筛查PC的主要生物标志物。PSA升高可能导致假阳性结果。因此，应研究更合适的标志物。在本研究中，测定了肿瘤性前列腺组织与非肿瘤组织中JPX和LINC00641的表达水平。

实验方法

制备了43对前列腺肿瘤组织和非肿瘤组织。通过RT-qPCR研究JPX和LINC00641的表达水平。

研究结果

与正常组织（其相邻的非肿瘤组织）相比，在PC组织中观察到LINC00641显著上调（2.47±0.5对1.41±0.2），JPX显著下调（1.42±0.6对2.83±1.0）。

结论与意义

PC患者中JPX和LINC00641的失调未来可作为PC的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/7e3487e896a0/RPS-16-493-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/ffe67f638cf6/RPS-16-493-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/0edb87fad931/RPS-16-493-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/7e3487e896a0/RPS-16-493-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/ffe67f638cf6/RPS-16-493-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/0edb87fad931/RPS-16-493-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe4e/8407155/7e3487e896a0/RPS-16-493-g003.jpg

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Metab Brain Dis. 2020 Dec;35(8):1309-1316. doi: 10.1007/s11011-020-00590-7. Epub 2020 Aug 18.
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design of two novel fusion proteins, p28-IL-24 and p28-M4, targeted to breast cancer cells.两种新型融合蛋白p28-IL-24和p28-M4的设计，其靶向乳腺癌细胞。
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lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling.lncRNA JPX/miR-33a-5p/Twist1 轴通过激活 Wnt/β-catenin 信号通路调节肺癌的发生和转移。
Mol Cancer. 2020 Jan 15;19(1):9. doi: 10.1186/s12943-020-1133-9.
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