Bernhard-Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Trends Parasitol. 2009 Nov;25(11):494-7. doi: 10.1016/j.pt.2009.07.008. Epub 2009 Sep 4.
Apical membrane antigen 1 (AMA1) plays an essential role in host cell invasion by apicomplexan parasites. A recent study by Collins et al. investigated the mode of action of an anti-AMA1 invasion-inhibitory antibody. They demonstrated the interference of this antibody with invasion complex formation, which was dependent in turn on a single conserved tyrosine residue in AMA1. Their findings reveal important new insights into parasite biology and are highly relevant for rational vaccine design.
顶端膜抗原 1（AMA1）在顶复门寄生虫感染宿主细胞过程中发挥着重要作用。Collins 等人最近研究了一种抗 AMA1 入侵抑制抗体的作用模式。他们证实了该抗体通过干扰 AMA1 中的一个单一保守酪氨酸残基来抑制入侵复合物的形成。他们的发现揭示了寄生虫生物学的重要新见解，对合理疫苗设计具有重要意义。
