脂联素基因+45T/G和+276G/T多态性与抗精神病药物所致体重增加
Adiponectin gene +45T/G and +276G/T polymorphism and antipsychotic-induced weight gain.
作者信息
Li Lehua, Wu Renrong, Zhao Jingping
机构信息
Mental Health Instittute, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Aug;34(8):693-6.
OBJECTIVE
To investigate whether antipsychotic-induced weight gain was associated with adiponectin gene +45T/G and +276G/T polymorphism.
METHODS
A case-matched study was done: 85 patients who gained more than 7% of their pre-drug body weight were designed to the study group and 85 patients who gained less than 7% of their pre-drug body weight served as the control group. Ligation diction reaction technique was used to analyze the frequencies of the +276G/T and +45T/G polymorphism of adiponectin gene.
RESULTS
The presence of +276G allele was significantly higher in the study group as compared with the control group.
CONCLUSION
Subjects with the +276G variant alleles may have a greater risk for weight gain after antipsychotic treatment.
目的
探讨抗精神病药物所致体重增加是否与脂联素基因+45T/G和+276G/T多态性有关。
方法
进行病例对照研究：将药物治疗前体重增加超过7%的85例患者设为研究组，将药物治疗前体重增加少于7%的85例患者作为对照组。采用连接酶检测反应技术分析脂联素基因+276G/T和+45T/G多态性的频率。
结果
与对照组相比，研究组中+276G等位基因的存在显著更高。
结论
携带+276G变异等位基因的受试者在抗精神病药物治疗后体重增加的风险可能更大。
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