Wu Renrong, Zhao Jingping, Shao Ping, Ou Jianjun, Chang Maihui
Central South University, Changsha, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Aug;36(8):720-3. doi: 10.3969/j.issn.1672-7347.2011.08.003.
To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T and -697G/C, histamine-1 receptor gene, leptine gene -2548G/A, and adiponectin gene +276G/T and +45T/G.
In the case-matched study, 85 patients who gained more than 7% of their pre-drug body weight served as the study group and another 85 patients who gained less than 7% of their pre-drug body weight served as the control group. The ligation diction reaction technique was used to analyze the frequencies of the -759C/T and -697G/C polymorphism of the HTR2C gene, -2548A/G polymorphism of leptin gene, +276G/T and +45T/G polymorphism of adiponectin gene and glu349asp polymorphism of H1 receptor gene.
The presence of the -759C allele, -697G allele, -2548A allele and +276G allele was significantly higher in the study group than that in the control group (P<0.05).
The -759C/T and -697G/C polymorphisms of the promoter region of 5HT(2)C receptor gene, -2548A/G polymorphisms of leptin gene and +276G/T polymorphisms of adiponectin gene may be associated with the antipsychotic induced weight gain. The glu349asp polymorphisms of histamine-1 receptor gene is not associated with antipsychotic induced weight gain.
确定抗精神病药物所致体重增加与5-羟色胺受体2C（HTR2C）基因-759C/T和-697G/C、组胺-1受体基因、瘦素基因-2548G/A以及脂联素基因+276G/T和+45T/G多态性之间的关联。
在病例对照研究中，85例药物治疗前体重增加超过7%的患者作为研究组，另外85例药物治疗前体重增加少于7%的患者作为对照组。采用连接酶检测反应技术分析HTR2C基因-759C/T和-697G/C多态性、瘦素基因-2548A/G多态性、脂联素基因+276G/T和+45T/G多态性以及组胺-1受体基因glu349asp多态性的频率。
研究组中-759C等位基因、-697G等位基因、-2548A等位基因和+276G等位基因的存在频率显著高于对照组（P<0.05）。
5-羟色胺受体2C（5HT(2)C）受体基因启动子区域的-759C/T和-697G/C多态性、瘦素基因-2548A/G多态性以及脂联素基因+276G/T多态性可能与抗精神病药物所致体重增加有关。组胺-1受体基因的glu349asp多态性与抗精神病药物所致体重增加无关。
