Okada Yumika, Ishikura Masaharu, Maoka Takashi
Life Science Institute, Yamaha Motor Co., Ltd., 3001-10 Kunou, Fukuroi, Shizuoka 437-0031, Japan.
Biosci Biotechnol Biochem. 2009 Sep;73(9):1928-32. doi: 10.1271/bbb.90078. Epub 2009 Sep 7.
Astaxanthin is a caroteonid that possesses strong antioxidant activity. Recently, many studies on biological activity have been reported. In general, the absorption of carotenoids is affected greatly by diet and by smoking. In this report, we investigated astaxanthin pharmacokinetics after administration of Haematococcus algal extract, a source of astaxanthin, to smokers and nonsmokers before and after a meal; astaxanthin was given before the meal to nonsmokers (n = 7), after the meal to nonsmokers (n = 6), and after the meal to smokers (n = 7), then serum samples were analyzed. The timing of administration greatly affected astaxanthin bioavailability including the area under the curve (AUC(0-168), 2,968 + or - 959 microg h/l in the before-meal group vs. 7,219 + or - 3,118 microg h/l in the after-meal group), indicating high availability in the after-meal group. Smoking also affected the pharmacokinetic parameters and reduced the half-life (t(1/2)) of astaxanthin elimination significantly.
虾青素是一种具有强大抗氧化活性的类胡萝卜素。最近，已有许多关于其生物活性的研究报道。一般来说，类胡萝卜素的吸收会受到饮食和吸烟的极大影响。在本报告中，我们研究了在吸烟者和非吸烟者饭前及饭后给予虾青素来源——雨生红球藻提取物后虾青素的药代动力学；在饭前给予非吸烟者（n = 7）、饭后给予非吸烟者（n = 6）以及饭后给予吸烟者（n = 7）虾青素，然后对血清样本进行分析。给药时间对虾青素的生物利用度有很大影响，包括曲线下面积（AUC(0 - 168)，饭前组为2,968 ± 959 μg h/l，饭后组为7,219 ± 3,118 μg h/l），表明饭后组的生物利用度较高。吸烟也会影响药代动力学参数，并显著降低虾青素消除的半衰期（t(1/2)）。
