Zhu Xiao, Chen Xi, Wang Matthew, Hu Honghua
School of Medicine, Jinhua University of Vocational Technology, Jinhua 321017, China.
Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua 321016, China.
Antioxidants (Basel). 2025 Jun 12;14(6):715. doi: 10.3390/antiox14060715.
Astaxanthin (AST) is a fat-soluble carotenoid antioxidant. AST exhibits multiple protective mechanisms, including its antioxidant, anti-inflammatory, immunomodulatory, anti-apoptotic, nervous system-protective, anti-tumor, and anti-fibrotic effects. These effects make it a promising compound for the prevention of chronic diseases. AST can protect the nervous system against neurodegenerative diseases such as Alzheimer's and Parkinson's disease. It also protects the liver and helps reduce the risk of chronic kidney disease. Additionally, it improves cardiovascular health and has anti-diabetic properties. This review aims to provide an updated overview covering the protective effects of AST against various chronic diseases, including its antioxidant, anti-inflammatory, and anti-apoptotic effects. We also discuss the strategies used for improving astaxanthin bioavailability and its potential as an adjuvant therapeutic agent.
虾青素(AST)是一种脂溶性类胡萝卜素抗氧化剂。AST具有多种保护机制,包括其抗氧化、抗炎、免疫调节、抗凋亡、神经保护、抗肿瘤和抗纤维化作用。这些作用使其成为预防慢性疾病的一种有前景的化合物。AST可以保护神经系统免受诸如阿尔茨海默病和帕金森病等神经退行性疾病的侵害。它还能保护肝脏并有助于降低慢性肾病的风险。此外,它能改善心血管健康并具有抗糖尿病特性。本综述旨在提供一份最新概述,涵盖AST对各种慢性疾病的保护作用,包括其抗氧化、抗炎和抗凋亡作用。我们还讨论了用于提高虾青素生物利用度的策略及其作为辅助治疗剂的潜力。