Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità Rome 00161, Italy.
Eur J Gastroenterol Hepatol. 2010 Feb;22(2):167-71. doi: 10.1097/MEG.0b013e328330d410.
The prevalence of viral hepatitis markers and of alcohol intake was evaluated in 106 and 99 Albanian patients with the diagnosis of viral and/or alcoholic chronic liver disease who were consecutively admitted to the University Hospital Center of Tirana, during 1995 and 2005, respectively.
A slight decrease in HBsAg (78 vs. 70%) and HBeAg (18 vs. 12%) prevalences were observed in patients admitted to the hospital during 2005 compared with those admitted during 1995, respectively. In both periods of time, hepatitis B virus (HBV) DNA (genotype D) tested positive in all HBsAg-positive patients and in 36% of HBsAg-negative patients. Anti-hepatitis C virus (HCV) prevalence (mainly observed after 30 years of age) was 14 versus 11%; anti-hepatitis Delta virus (HDV) prevalence (more frequently present in young age group patients) was 9 versus 7% during 1995 and 2005, respectively. Among patients who reported alcohol intake, alcoholic liver disease (HBsAg and anti-HCV negative) was diagnosed in 35 and in 57% of patients admitted during 1995 and 2005, respectively (P = 0.05).
In Albanian patients with chronic liver disease, we have found that: (i) HBV remained the most important aetiologic factor of chronic liver disease; HDV and HCV prevalences were still low, (ii) in HBsAg-positive patients, HBeAg-negative chronic hepatitis prevailed, (iii) in HBsAg-negative patients, HBV DNA prevalence was high, (iv) during the last decade, an increased prevalence of alcohol intake in the aetiology of chronic liver disease was observed.
在 1995 年至 2005 年期间，连续收治于地拉那大学医院中心的 106 名和 99 名诊断为病毒性和/或酒精性慢性肝病的阿尔巴尼亚患者中，评估了病毒肝炎标志物和酒精摄入的流行情况。
与 1995 年相比，2005 年入院的患者 HBsAg（78%对 70%）和 HBeAg（18%对 12%）的流行率略有下降。在这两个时期，所有 HBsAg 阳性患者和 36%的 HBsAg 阴性患者的乙型肝炎病毒（HBV）DNA（基因型 D）检测均为阳性。抗丙型肝炎病毒（HCV）的流行率（主要在 30 岁以后观察到）分别为 14%对 11%；抗乙型肝炎病毒（HDV）的流行率（在年轻患者组中更为常见）分别为 9%对 7%，1995 年和 2005 年。在报告饮酒的患者中，1995 年和 2005 年入院的患者中，分别诊断为酒精性肝病（HBsAg 和抗-HCV 阴性）的患者占 35%和 57%（P = 0.05）。
在患有慢性肝病的阿尔巴尼亚患者中，我们发现：（i）HBV 仍然是慢性肝病最重要的病因；HDV 和 HCV 的流行率仍然较低；（ii）在 HBsAg 阳性患者中，以 HBeAg 阴性慢性肝炎为主；（iii）在 HBsAg 阴性患者中，HBV DNA 的流行率较高；（iv）在过去十年中，慢性肝病病因中酒精摄入的流行率有所增加。
