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Mouse fertility is not dependent on the CREB coactivator Crtc1.

作者信息

Breuillaud Lionel, Halfon Olivier, Magistretti Pierre J, Pralong François P, Cardinaux Jean-René

出版信息

Nat Med. 2009 Sep;15(9):989-90; author reply 991. doi: 10.1038/nm0909-989.

DOI:10.1038/nm0909-989
PMID:19734865
Abstract
摘要

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Mouse fertility is not dependent on the CREB coactivator Crtc1.小鼠的生育能力不依赖于CREB共激活因子Crtc1。
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2
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1
Genetic differences among C57BL/6 substrains.C57BL/6亚系之间的遗传差异。
Exp Anim. 2009 Apr;58(2):141-9. doi: 10.1538/expanim.58.141.
2
The geometry of leptin action in the brain: more complicated than a simple ARC.瘦素在大脑中的作用机制：比简单的弓状核更为复杂。
Cell Metab. 2009 Feb;9(2):117-23. doi: 10.1016/j.cmet.2008.12.001.
3
The Creb1 coactivator Crtc1 is required for energy balance and fertility.Creb1共激活因子Crtc1是能量平衡和生育能力所必需的。
J Neurosci. 2025 Jan 29;45(5):e0786242024. doi: 10.1523/JNEUROSCI.0786-24.2024.
4
Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior.Crtc1 的缺失导致与抑郁样行为相关的海马神经能量障碍。
Mol Psychiatry. 2022 Nov;27(11):4485-4501. doi: 10.1038/s41380-022-01791-5. Epub 2022 Oct 12.
5
New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity.关于CREB调节转录共激活因子1在抑郁症和共病肥胖症中的关键作用的新见解
Front Mol Neurosci. 2022 Feb 15;15:810641. doi: 10.3389/fnmol.2022.810641. eCollection 2022.
6
Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends?多种瘦素信号通路在代谢和生殖调控中的作用：殊途同归？
Int J Mol Sci. 2021 Aug 26;22(17):9210. doi: 10.3390/ijms22179210.
7
Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose.Crtc1基因缺陷可能通过调节白色脂肪中的PPARγ信号通路导致肥胖。
Front Cell Dev Biol. 2021 Apr 12;9:602529. doi: 10.3389/fcell.2021.602529. eCollection 2021.
8
Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose.全基因组关联分析揭示了影响狮头鹅产蛋性能的关键基因。
Front Genet. 2020 Jan 28;10:1391. doi: 10.3389/fgene.2019.01391. eCollection 2019.
9
Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients.精神药物诱导的 CRTC1 基因遗传-表观遗传调控与精神科患者前瞻性研究中的早期体重增加有关。
Clin Epigenetics. 2019 Dec 26;11(1):198. doi: 10.1186/s13148-019-0792-0.
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Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.抑郁的 Crtc1 基因敲除小鼠模型中能量平衡和昼夜节律性运动活动的性别特异性改变。
Transl Psychiatry. 2017 Dec 8;7(12):1269. doi: 10.1038/s41398-017-0023-4.
Nat Med. 2008 Oct;14(10):1112-7. doi: 10.1038/nm.1866. Epub 2008 Aug 31.
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Mol Endocrinol. 2008 Aug;22(8):1908-23. doi: 10.1210/me.2007-0455. Epub 2008 Jun 11.
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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.胰岛素通过抑制辅激活因子TORC2来调节糖异生。
Nature. 2007 Sep 20;449(7160):366-9. doi: 10.1038/nature06128. Epub 2007 Sep 5.
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Endocrinology. 2007 Oct;148(10):4821-8. doi: 10.1210/en.2007-0154. Epub 2007 Jul 26.
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TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity.TORC1是一种参与海马体长期突触可塑性的钙和环磷酸腺苷敏感的巧合探测器。
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Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling.辅激活因子TORC2在调节肝脏葡萄糖输出和胰岛素信号传导中的双重作用。
Cell Metab. 2005 Nov;2(5):331-8. doi: 10.1016/j.cmet.2005.09.008.
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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.CREB 共激活因子 TORC2 是空腹葡萄糖代谢的关键调节因子。
Nature. 2005 Oct 20;437(7062):1109-11. doi: 10.1038/nature03967. Epub 2005 Sep 7.
10
Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.通过TORC蛋白的调控性核转运激活cAMP反应元件介导的基因表达。
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