Salgado Jocelem Mastrodi, Mansi Débora Niero, Gagliardi Antonio
Department of Agroindustry, Foods and Nutrition, University of São Paulo/Escola Superior de Agricultura Luiz de Queiroz, Piracicaba, São Paulo, Brazil.
J Med Food. 2009 Aug;12(4):722-7. doi: 10.1089/jmf.2008.0157.
Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicine as a diuretic, anti-influenza, anti-inflammatory, anticonvulsion, and hypoglycemic agent. The objective of this study was to analyze the effects of aqueous extracts from the leaves and stem of C. sicyoides L., administered for 60 days, for the control of glycemia in alloxan (monohydrate)-induced diabetic rats, monitored by biomarkers. Data obtained in this study confirmed that C. sicyoides has a hypoglycemic effect on diabetic rats. Administration of its aqueous extracts promoted a 45% decrease in glucose levels after 60 days of administration. Furthermore, indices of hepatic glycogen, blood glucose, C-reactive peptide, and fructosamine were found to be efficient biomarkers to monitor diabetes in rats.
糖尿病是一种无法治愈的慢性退行性疾病，全球数以百万计的人患有此病，且在任何年龄段都可能引发危及生命的并发症。西番莲属植物（Cissus sicyoides L.）是一种藤本植物，在巴西大量生长，尤其是在亚马逊地区。其治疗特性在传统医学中被广泛用作利尿剂、抗流感剂、抗炎剂、抗惊厥剂和降血糖剂。本研究的目的是分析西番莲属植物叶和茎的水提取物连续给药60天对四氧嘧啶（一水合物）诱导的糖尿病大鼠血糖控制的影响，并通过生物标志物进行监测。本研究获得的数据证实，西番莲属植物对糖尿病大鼠具有降血糖作用。给药60天后，其水提取物的施用使血糖水平降低了45%。此外，肝糖原、血糖、C反应蛋白和果糖胺指标被发现是监测大鼠糖尿病的有效生物标志物。
