Combretum micranthum（Combretaceae）叶水提物对正常和四氧嘧啶诱导糖尿病大鼠的降血糖活性。
Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats.
机构信息
Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Ali Akilu Road, Sokoto, Nigeria.
出版信息
J Ethnopharmacol. 2010 May 4;129(1):34-7. doi: 10.1016/j.jep.2010.02.008. Epub 2010 Feb 26.
AIM OF THE STUDY
To investigate antidiabetic effect of the leaves of Combretum micranthum G. Don, a medicinal plant used for treating diabetes in Northwestern Nigeria.
MATERIALS AND METHODS
Three doses (100mg/kg, 200mg/kg and 400mg/kg) of the aqueous leaf extract of Combretum micranthum were administered to normal glucose loaded, subdiabetic and diabetic rats.
RESULTS
Of the doses tested, 100mg/kg of the extract was the most effective. It produces a significant hypoglycaemic and antidiabetic activity comparable to the effect of standard drug (0.6 mg/kg glibenclemide).
CONCLUSION
This study demonstrated the potential antidiabetic property of aqueous leaf extract of Combretum micranthum thus justifying its traditional usage.
研究目的
研究用于治疗尼日利亚西北部糖尿病的药用植物圆叶牡荆的叶子的降血糖作用。
材料和方法
给正常糖耐量负荷、亚糖尿病和糖尿病大鼠灌胃三种剂量（100mg/kg、200mg/kg 和 400mg/kg）的圆叶牡荆水提物。
结果
在所测试的剂量中，100mg/kg 的提取物最为有效。它产生了显著的降血糖和抗糖尿病活性，可与标准药物（0.6mg/kg 格列本脲）的效果相媲美。
结论
这项研究表明圆叶牡荆的水提物具有潜在的抗糖尿病特性，因此证实了其传统用途。
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