Reddy P, Zembower T R, Ison M G, Baker T A, Stosor V
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Transpl Infect Dis. 2010 Feb;12(1):87-93. doi: 10.1111/j.1399-3062.2009.00445.x. Epub 2009 Sep 7.
Multi-drug resistant (MDR) gram-negative infections among solid organ transplant (SOT) recipients have long been associated with high morbidity and mortality. Acinetobacter baumannii has emerged as a potent nosocomial pathogen with the recent acquisition of resistance to broad-spectrum beta-lactams, aminoglycosides, fluoroquinolones, and most notably, carbapenems. Despite a national rise in carbapenem-resistant A. baumannii (CRAB) infections, outcomes among SOT recipients with this emerging MDR pathogen are largely unknown. This single-center cohort is the first to describe the characteristics, complications, and outcomes among abdominal organ transplant recipients with CRAB. The current study suggests that SOT patients with CRAB suffer from prolonged hospitalization, infection with other MDR organisms, allograft dysfunction and loss, and high overall infection-related mortality.
实体器官移植（SOT）受者中的多重耐药（MDR）革兰氏阴性菌感染长期以来一直与高发病率和死亡率相关。鲍曼不动杆菌已成为一种强大的医院病原体，最近它获得了对广谱β-内酰胺类、氨基糖苷类、氟喹诺酮类，最显著的是对碳青霉烯类的耐药性。尽管全国范围内耐碳青霉烯鲍曼不动杆菌（CRAB）感染有所增加，但这种新兴的MDR病原体在SOT受者中的预后情况很大程度上尚不清楚。这个单中心队列研究首次描述了腹部器官移植受者中CRAB的特征、并发症和预后。当前研究表明，患有CRAB的SOT患者住院时间延长，感染其他MDR病原体，移植器官功能障碍和丧失，以及总体感染相关死亡率很高。
