The Procter & Gamble Company, Cincinnati, Ohio 45241, USA.
J Cosmet Dermatol. 2009 Sep;8(3):228-33. doi: 10.1111/j.1473-2165.2009.00444.x.
The periorbital area is a key wrinkle-prone region, where the first signs of aging usually appear.
To demonstrate the ability of new anti-aging moisturizing products to improve overall smoothness and wrinkle depth appearance in the periorbital region via the Fast Optical in vivo Topometry of Human Skin (FOITS).
Two double-blind, randomized, controlled, split-face studies (n = 42, Study 1; n = 35, Study 2) were conducted in women 30-70 years old with moderate to distinct periorbital wrinkles. Subjects applied 0.5 g of individual products to half their face twice daily for 4 weeks. Four test products containing niacinamide, the peptides Pal-KT and Pal-KTTKS, and carnosine were used and included a daytime SPF 30 lotion also containing antioxidants, a night cream, an eye cream also containing caffeine, and a wrinkle treatment containing retinyl propionate. The wrinkle treatment was only tested in Study 2. The FOITS technique was used to measure changes in periorbital R(a) (mean roughness) and R(z) (average maximum roughness) at 2 and 4 weeks.
In Study 1, the daytime SPF 30 lotion, night cream, and eye cream significantly improved crow's feet smoothness after 4 weeks relative to no treatment. After 4 weeks, the daytime SPF 30 lotion and night cream, but not the eye cream, were significantly better than no treatment at improving R(z). In Study 2, the night cream, eye cream, and wrinkle treatment, but not the daytime SPF 30 lotion, significantly improved both R(a) and R(z) after 4 weeks. To increase power and precision of estimates, a meta-analysis was performed; the pooled data showed all three products were significantly better than no treatment at improving R(a) and R(z) after 4 weeks.
Four weeks of treatment with these products was shown to improve the smoothness of periorbital skin and to reduce the apparent depth of larger wrinkles.
眶周区域是一个容易出现皱纹的关键区域，通常会出现衰老的最初迹象。
通过快速光学活体皮肤人体测量术（FOITS）展示新的抗衰老保湿产品改善眶周区域整体平整度和皱纹深度外观的能力。
在年龄 30-70 岁、眶周有中度至明显皱纹的女性中进行了两项双盲、随机、对照、左右半脸对照研究（研究 1：n=42；研究 2：n=35）。受试者每天两次在半边脸部涂抹 0.5 克的各产品，连续 4 周。使用了 4 种含有烟酰胺、肽 Pal-KT 和 Pal-KTTKS 以及肌肽的测试产品，其中包括含有抗氧化剂的日间 SPF30 乳液、晚霜、含有咖啡因的眼霜和含有视黄醇丙酸酯的皱纹治疗剂。仅在研究 2 中测试了皱纹治疗剂。使用 FOITS 技术测量 2 周和 4 周时眶周 R(a)（平均粗糙度）和 R(z)（平均最大粗糙度）的变化。
在研究 1 中，与未治疗组相比，日间 SPF30 乳液、晚霜和眼霜在 4 周后显著改善了鱼尾纹的平整度。4 周后，与未治疗组相比，日间 SPF30 乳液和晚霜显著改善了 R(z)，但眼霜没有。在研究 2 中，晚霜、眼霜和皱纹治疗剂，而不是日间 SPF30 乳液，在 4 周后显著改善了 R(a)和 R(z)。为了增加估计的功效和精度，进行了荟萃分析；汇总数据显示，在 4 周后，所有三种产品在改善 R(a)和 R(z)方面均显著优于未治疗组。
这些产品治疗 4 周可改善眶周皮肤的平整度并减少较大皱纹的表观深度。
