哺乳动物雌性性别决定中的互补途径。
Complementary pathways in mammalian female sex determination.
作者信息
Nef Serge, Vassalli Jean-Dominique
机构信息
Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland.
出版信息
J Biol. 2009 Sep 2;8(8):74. doi: 10.1186/jbiol173.
Abstract
In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/beta-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.
摘要
在哺乳动物中，胚胎的性别由性腺的命运决定。最近的一些论文，包括发表在《BMC发育生物学》上的一篇论文，揭示了卵巢发育的分子调控机制，并表明R-spondin1/Wnt4/β-连环蛋白信号通路和Foxl2转录因子以互补的方式发挥作用，促进卵巢命运并抑制睾丸发育。
Zotero 插件