Sossai P, Barbazza R
Gastroenterology Unit-Department of Medicine, City Hospital, Feltre, Italy.
Am J Gastroenterol. 1990 Jul;85(7):829-32.
The aim of this work was to study the relationship between intestinal metaplasia and dysplasia in gastric ulcers and their tissue repair in 223 patients with 236 gastric ulcers found endoscopically and treated with H2 blockers. The average duration of follow-up for the men was 32.4 months (range, 12-87 months) and for the women 42.5 months (range, 12-88 months). In 112 patients (50.2%) with 118 gastric ulcers, intestinal metaplasia in the different types was observed. The data obtained allow us to state that severe dysplasia and gastric cancer can occur only in a restricted number of patients with intestinal metaplasia in gastric ulcers and/or gastric ulcer tissue repair (two in our study, more than 60 yr old), and only in the forms with sulphomucins, more precisely type III. In relation to the fact that gastric ulcers rarely become carcinoma, the intestinal metaplasia frequently observed should not be considered "precancerous", as such, but could become so in the presence of several factors which, excluding age, did not emerge from our study.
本研究旨在探讨223例经内镜检查发现并接受H2受体阻滞剂治疗的236处胃溃疡患者的肠化生与发育异常之间的关系及其组织修复情况。男性患者的平均随访时间为32.4个月（范围12 - 87个月），女性患者为42.5个月（范围12 - 88个月）。112例（50.2%）患者的118处胃溃疡出现了不同类型的肠化生。所获数据使我们能够指出，严重发育异常和胃癌仅在少数胃溃疡伴有肠化生和/或胃溃疡组织修复的患者中发生（本研究中有2例，年龄超过60岁），且仅发生在含硫酸黏蛋白的类型中，更确切地说是III型。鉴于胃溃疡很少发生癌变，频繁观察到的肠化生本身不应被视为“癌前病变”，但在存在多种因素（年龄除外，本研究未发现这些因素）的情况下可能会成为癌前病变。
