Matsukura N, Suzuki K, Kawachi T, Aoyagi M, Sugimura T, Kitaoka H, Numajiri H, Shirota A, Itabashi M, Hirota T
J Natl Cancer Inst. 1980 Aug;65(2):231-40.
Intestinal metaplasia of the human stomach was classified into two types, complete and incomplete. The complete type was associated with the intestinal marker enzymes sucrose alpha-D-glucohydrolase, alpha, alpha-trehalase, aminopeptidase (microsomal) (APM), and alkaline phosphatase (ALP). Tissue of this type contained goblet cells and Paneth's cells but not high-iron diamine (HID)-positive mucin staining with HID-Alcian blue. The incomplete type of intestinal metaplasia was associated with sucrose alpha-D-glucohydrolase, APM, goblet cells, and HID-positive mucin but not with alpha, alpha-trehalase, ALP, or Paneth's cells. For the examination of the distribution of the complete and incomplete types in 84, 27, and 16 resected specimens of human stomach with gastric carcinoma, gastric ulcer, and duodenal ulcer, respectively, disaccharidases were located with Tes-Tape. Specimens with intestinal metaplasia were divided into three classes: complete type only (class I), incomplete type only (class II), and a mixture of areas of the complete and incomplete types (class III). Of the 84 specimens from patients with gastric carcinoma, intestinal metaplasia was found in 76 (01%), and the percentages of specimens of classes I, II, and III were 32, 22, and 46, respectively. In these specimens, the percent incidence of class I increased and that of class II decreased with age. Of the 27 specimens from patients with gastric ulcer, 16 (59%) shopwed intestinal metaplasia and 10 of the 16 (63%) specimens were of class II. Of the 16 specimens from patients with duodenal ulcer, only 3 (19%) specimens showed intestinal metaplasia and all of them were of class II. The relationships of the complete and incomplete types of intestinal metaplasia to gastric carcinoma wre studied in 26 foci of minute carcinoma of the stomach less than 5 mm in largest diameter. Nineteen of 20 (05%) foci of the intestinal type of minute carcinoma were surrounded by intestinal metaplasia and 16 foci (80%) were surrounded by the incomplete type of intestinal metaplasia.
人类胃的肠化生分为两种类型，即完全型和不完全型。完全型与肠标记酶蔗糖α-D-葡萄糖水解酶、α,α-海藻糖酶、氨基肽酶（微粒体）（APM）和碱性磷酸酶（ALP）相关。这种类型的组织含有杯状细胞和潘氏细胞，但高铁二胺（HID）-阿尔辛蓝染色时无HID阳性黏液染色。不完全型肠化生与蔗糖α-D-葡萄糖水解酶、APM、杯状细胞和HID阳性黏液相关，但与α,α-海藻糖酶、ALP或潘氏细胞无关。为了分别检查84例、27例和16例分别患有胃癌、胃溃疡和十二指肠溃疡的人类切除胃标本中完全型和不完全型的分布情况，用 Tes-Tape 定位二糖酶。有肠化生的标本分为三类：仅完全型（I类）、仅不完全型（II类）以及完全型和不完全型区域混合（III类）。在84例胃癌患者的标本中，76例（90.1%）发现有肠化生，I类、II类和III类标本的百分比分别为32%、22%和46%。在这些标本中，I类的发生率随年龄增加而升高，II类的发生率随年龄降低。在27例胃溃疡患者的标本中，16例（59%）显示有肠化生，其中10例（63%）属于II类。在16例十二指肠溃疡患者的标本中，仅3例（19%）显示有肠化生，且均为II类。在26个最大直径小于5mm的胃微小癌病灶中研究了完全型和不完全型肠化生与胃癌的关系。20个肠型微小癌病灶中有19个（95%）被肠化生包围，16个病灶（80%）被不完全型肠化生包围。
