Materia A, Silecchia G, Genco A, Spaziani E, De Leo A, Pizzuto G, Basso N
II Clinica Chirurgica, University La Sapienza, Rome, Italy.
Digestion. 1990;45(3):153-7. doi: 10.1159/000200237.
The effect of somatostatin-14 (SST), at doses utilized in clinical practice, on gastric intraluminal prostaglandin (PG) E2 release was evaluated in 8 endoscopically normal subjects, in 6 patients with benign gastric ulcer and in 8 patients with gastric adenocarcinoma. In normal subjects, SST induced a significant increase in gastric intraluminal PGE2 concentration and output, whereas it did not augment the concentration and output of PGE2 in patients with gastric ulcer and with gastric cancer. The altered PG response to SST stimulation shown by gastric ulcer and gastric cancer patients may be related to a modified cell population in the gastric mucosa and/or to a defective regulation of this local gastric mucosal mediator.
在8名内镜检查正常的受试者、6名良性胃溃疡患者和8名胃腺癌患者中，评估了临床实践中使用剂量的生长抑素-14（SST）对胃腔内前列腺素（PG）E2释放的影响。在正常受试者中，SST可使胃腔内PGE2浓度和输出量显著增加，而在胃溃疡患者和胃癌患者中，SST并未增加PGE2的浓度和输出量。胃溃疡和胃癌患者对SST刺激的PG反应改变，可能与胃黏膜中细胞群的改变和/或该局部胃黏膜介质的调节缺陷有关。
