Lee Y C, Chang K J, Lu F J, Yang P C
Department of Surgery, College of Medicine, National Taiwan University, Taipei, R.O.C.
J Formos Med Assoc. 1990 Feb;89(2):104-9.
Macro creatine kinase type 2 (MCK-2), an atypical cathodically migrating creatine kinase isoenzyme, was first detected in the serum of a breast cancer patient in 1978. In recent years, MCK-2 was also found in the sera of several malignancies and has been proposed as a potential tumor marker. Forty two patients with lung cancer. The rates of MCK-2 presence in serum were 56.8%, 29.6%, and 0%, respectively, for primary lung cancer, inflammatory lung disease and normal controls. In primary lung cancer, the rate of presence of MCK-2 was higher than CEA (40.0%), and appeared more frequently in epidermoid cancer (71.3%) and in stages 3 and 4 (65.4%). Serial examinations postoperatively showed that MCK-2 became negative after resection. Carcinoembryonic antigen, MCK-2 or a combination of both was evaluated as a diagnostic aid in 37 patients with a peripheral pulmonary nodule. Sensitivity, specificity and accuracy were 32.0%, 90.9%, 50.0%, 36.4%, 93.3%, 59.5%; 43.8%, 90.5%, 70.3%, respectively, for CEA, MCK-2, and CEA plus MCK-2. It is concluded that MCK-2 is comparable to CEA as a tumor marker in lung cancer. The combination of MCK-2 and CEA is of value as a diagnostic aid in patients with a peripheral pulmonary nodule.
2型巨肌酸激酶（MCK - 2）是一种非典型的向阴极迁移的肌酸激酶同工酶，于1978年首次在一名乳腺癌患者的血清中被检测到。近年来，在多种恶性肿瘤患者的血清中也发现了MCK - 2，并被提议作为一种潜在的肿瘤标志物。42例肺癌患者。原发性肺癌、炎性肺病和正常对照者血清中MCK - 2的阳性率分别为56.8%、29.6%和0%。在原发性肺癌中，MCK - 2的阳性率高于癌胚抗原（CEA，40.0%），在鳞状细胞癌（71.3%）以及3期和4期（65.4%）中出现得更为频繁。术后的系列检查显示，切除后MCK - 2变为阴性。对37例周围型肺结节患者评估癌胚抗原、MCK - 2或两者联合检测对诊断的辅助作用。CEA、MCK - 2以及CEA加MCK - 2的敏感性、特异性和准确性分别为32.0%、90.9%、50.0%；36.4%、93.3%、59.5%；43.8%、90.5%、70.3%。结论是，MCK - 2作为肺癌的肿瘤标志物与CEA相当。MCK - 2和CEA联合检测对周围型肺结节患者的诊断有辅助价值。
