Dominiczak K, Mikulski T
Med Pr. 1977;28(3):179-87.
Male rats weighing 180-220 g were given CdSO4, 0,4 mg/kg body weight subcutaneously once a week for 6-12 months. The animals were killed after 6, 9, 12 months and following blood serum levels were determined: total protein, albumin, globulin, GPT, GOT, Al.P. and urea. The tissue tissue samples from liver and kidneys were examined histologically (acid and alkaline phosphatase). After 9 months, the difference between values of biochemical indices in the exposed and control groups was statistically significant. It has been found that the observed biochemical indices show correlation with the extent of morphological changes in liver and kidneys. These degenerative changes became more intense in the liver than in the kidneys.
体重180 - 220克的雄性大鼠每周皮下注射一次硫酸镉，剂量为0.4毫克/千克体重，持续6至12个月。在6、9、12个月后处死动物，并测定以下血清水平：总蛋白、白蛋白、球蛋白、谷丙转氨酶、谷草转氨酶、碱性磷酸酶和尿素。对肝脏和肾脏的组织样本进行组织学检查（酸性和碱性磷酸酶）。9个月后，暴露组和对照组生化指标值之间的差异具有统计学意义。已发现观察到的生化指标与肝脏和肾脏形态变化的程度相关。这些退行性变化在肝脏中比在肾脏中更为明显。
