Martorell-Calatayud Antonio, Botella-Estrada Rafael, Sanmartín-Jimenez Onofre, Requena Celia, Guillén-Barona Carlos, Sangüeza Omar Pastor
Dermatology Department, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
J Cutan Pathol. 2010 Mar;37(3):330-5. doi: 10.1111/j.1600-0560.2009.01417.x. Epub 2009 Sep 8.
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. In early stages of the disease many different clinicopathologic variants have been observed. Currently, a papular variant of MF which is characterized by a good prognosis has been described.
Because only seven cases have been reported in the literature, clinical and morphological data of this variant are not well established. We report the clinical and histopathological characteristics of two new patients with papular mycosis fungoides and review the previous cases reported in the literature.
The two cases of this early variant of MF were characterized by the presence of papules which, unlike the papules of lymphomatoid papulosis, did not show a tendency for spontaneous resolution. Histologic examination confirmed the diagnosis of MF in all cases. Immunohistochemical staining for CD30 was negative in all two cases. Follow-up data of our two patients confirmed the non-aggressive behavior of the disease, confirming that the lesions were not manifestations of advanced MF.
Papular MF is a new variant of early MF characterized by a good prognosis in the long term follow- up. Thus, it should be added to the long list of clinicopathologic subtypes of MF.
蕈样肉芽肿（MF）是最常见的皮肤T细胞淋巴瘤类型。在疾病的早期阶段，已观察到许多不同的临床病理变体。目前，已描述了一种预后良好的MF丘疹变体。
由于文献中仅报道了7例，该变体的临床和形态学数据尚未完全确立。我们报告了2例新的丘疹型蕈样肉芽肿患者的临床和组织病理学特征，并回顾了文献中报道的既往病例。
这2例早期MF变体的特征是存在丘疹，与淋巴瘤样丘疹病的丘疹不同，这些丘疹没有自发消退的倾向。组织学检查在所有病例中均确诊为MF。2例患者的CD30免疫组化染色均为阴性。我们2例患者的随访数据证实了该疾病的非侵袭性，证实这些病变不是晚期MF的表现。
丘疹型MF是早期MF的一种新变体，在长期随访中预后良好。因此，应将其添加到MF的众多临床病理亚型中。
