Bröjer Caroline, Agren Erik O, Uhlhorn Henrik, Bernodt Karin, Mörner Torsten, Jansson Désirée S, Mattsson Roland, Zohari Siamak, Thorén Peter, Berg Mikael, Gavier-Widén Dolores
Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), SE75189, Uppsala, Sweden.
J Vet Diagn Invest. 2009 Sep;21(5):579-87. doi: 10.1177/104063870902100501.
Highly pathogenic avian influenza (HPAI) subtype H5N1 is an infectious systemic viral disease that results in high morbidity and mortality in poultry, and has been reported in a wide range of wild bird species during the last few years. An outbreak of HPAI H5N1 occurred in wild birds in Sweden in 2006 that affected several duck species, geese, swans, gulls, and raptors. Tufted ducks (Aythya fuligula) accounted for the largest number of positive cases and, therefore, were selected for more in-depth histologic and immunohistochemical evaluations. The main histologic lesions associated with the presence of avian influenza antigen were found in the brain, pancreas, and upper respiratory tract. Other tissues in which influenza antigen was variably found included liver, lung, adrenal glands, kidneys, and peripheral nerve ganglia. The current study describes the pathology and viral tissue targeting of H5N1 by using histology, polymerase chain reaction, and immunohistochemistry, and highlights the range and variation in the presentation of the natural disease in tufted ducks.
高致病性禽流感（HPAI）H5N1亚型是一种传染性全身性病毒病，可导致家禽的高发病率和高死亡率，并且在过去几年中已在多种野生鸟类中被报道。2006年，瑞典的野生鸟类中发生了HPAI H5N1疫情，涉及几种鸭类、鹅、天鹅、海鸥和猛禽。凤头潜鸭（Aythya fuligula）的阳性病例数最多，因此被选作更深入的组织学和免疫组织化学评估对象。与禽流感抗原存在相关的主要组织学病变见于脑、胰腺和上呼吸道。其他偶尔发现流感抗原的组织包括肝脏、肺、肾上腺、肾脏和外周神经节。本研究通过组织学、聚合酶链反应和免疫组织化学描述了H5N1的病理学及病毒组织靶向性，并强调了凤头潜鸭自然疾病表现的范围和变异性。
