Hao Xinyu, Kuriyama Masami, Chen Qian, Yamamoto Yasutomo, Yamada Ken-ichi, Tomioka Kiyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Org Lett. 2009 Oct 1;11(19):4470-3. doi: 10.1021/ol901866y.
Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-phosphinoylaldimines was realized by the steric tuning of a diphenylphosphorus moiety to a di(o-tolyl)phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding diarylmethylamines in high yield.
通过将手性酰胺单膦烷的二苯基磷部分空间调谐为二（邻甲苯基）磷部分，实现了铑催化的芳基硼酸酯对N-磷酰亚胺的高度对映选择性加成。在二氧六环 - 丙醇的5:1溶剂混合物中存在MS 4A对于高产率得到相应的二芳基甲胺至关重要。
