嵌段共聚物的酶促自组装

Enzymatically triggered self-assembly of block copolymers.

作者信息

Amir Roey J, Zhong Sheng, Pochan Darrin J, Hawker Craig J

机构信息

Materials Research Laboratory and Department of Materials, University of California, Santa Barbara, California 93106, USA.

出版信息

J Am Chem Soc. 2009 Oct 7;131(39):13949-51. doi: 10.1021/ja9060917.

DOI:10.1021/ja9060917

PMID:19739628

Abstract

The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction opens the way for novel and exciting applications such as enzymatic-triggered activation of surfaces and formation of nanostructures in vivo in a highly controlled manner.

摘要

已表明，乙烯基单体与可裂解酶底物的聚合反应会生成水溶性双亲水嵌段共聚物，在对二嵌段共聚物进行酶促活化后，这些共聚物会变成两亲性，并自组装成胶体纳米结构。通过酶促反应改变聚合物材料化学和物理特性的能力，为新颖且令人兴奋的应用开辟了道路，例如酶触发的表面活化以及在体内以高度可控的方式形成纳米结构。