Hung J, Whitford E G, Parsons R W, Hillman D R
Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Lancet. 1990 Aug 4;336(8710):261-4. doi: 10.1016/0140-6736(90)91799-g.
To examine the hypothesis that sleep apnoea is a risk factor for ischaemic heart disease, overnight polysomnography was performed in 101 unselected male survivors of acute myocardial infarction (MI) aged less than 66 yr and in 53 male subjects of similar age without evidence of ischaemic heart disease. The apnoea index (AI, number of apnoea episodes per hour of sleep) was 6.9 (SEM 1.2) in the MI patients versus 1.4 (0.3) in the control subjects. After adjustment for age, body mass index, hypertension, smoking, and cholesterol level, multiple logistic regression analysis identified the top quartile of AI (greater than 5.3) as an independent predictor of MI patients. The relative risk for myocardial infarction between the highest and lowest quartiles of AI was 23.3 (95% confidence interval 3.9-139.9).
为检验睡眠呼吸暂停是缺血性心脏病危险因素这一假说，对101名年龄小于66岁的急性心肌梗死（MI）男性幸存者及53名年龄相仿且无缺血性心脏病证据的男性受试者进行了夜间多导睡眠图检查。MI患者的呼吸暂停指数（AI，每小时睡眠中的呼吸暂停发作次数）为6.9（标准误1.2），而对照组受试者为1.4（0.3）。在对年龄、体重指数、高血压、吸烟和胆固醇水平进行校正后，多因素逻辑回归分析确定AI最高四分位数（大于5.3）为MI患者的独立预测因素。AI最高和最低四分位数之间心肌梗死的相对风险为23.3（95%置信区间3.9 - 139.9）。
