Dutta Savi, Singhal A K, Suryan Varsha, Chandra Nimai Chand
Department of Biochemistry, Shree Guru Gobind Singh Tricentenary University, Gurugram, Haryana 122505 India.
Present Address: Department of Biochemistry, Al Falah School of Medical Sciences & Research Centre, Faridabad, Haryana India.
Indian J Clin Biochem. 2024 Apr;39(2):168-178. doi: 10.1007/s12291-023-01157-w. Epub 2023 Oct 13.
The authors sought to correlate the complex sequel of obesity with various parameters known to develop metabolic syndrome viz. insulin resistance, dyslipidemia, hypertension etc., as these anomalies are linked to vascular atherosclerosis and outbreak of cardiovascular and cerebrovascular diseases. A comprehensive online survey using MEDLINE, Scopus, PubMed and Google Scholar was conducted for relevant journals from 1970 till present time (2023) with key search terms like: 'obesity', 'leptin', type-2 diabetes', 'atherosclerosis', 'cardiovascular and cerebrovascular diseases'. The findings of the reports were compared and correlated. The information was then collated for developing this review. Reports showed that in human obesity, hyper-leptinemia could induce hyperglycemia, which in turn templates hypercholesterolemia. Persisting hypercholesterolemia over a period of time may en-route atherosclerosis in blood vessels. Thus obesity has been considered as a template for originating hyperglycemia, hypercholesterolemia and outbreak of vascular atherogenesis or in other words, obesity in long run can trigger atherosclerosis and its related disorders e.g. heart attack and stroke. Literature survey shows that primarily, co-morbidities of human obesity start with leptin and insulin resistance and then multiplies with metabolic irregularities to an extreme that results in pathogenesis of heart attack and stroke. Atherosclerosis associated cardiovascular and cerebrovascular events are independent risks of obese subjects and particularly in the cases of persisting obesity.
作者试图将肥胖的复杂后果与已知会引发代谢综合征的各种参数联系起来，即胰岛素抵抗、血脂异常、高血压等，因为这些异常与血管动脉粥样硬化以及心血管和脑血管疾病的爆发有关。使用MEDLINE、Scopus、PubMed和谷歌学术进行了一项全面的在线调查，调查对象为1970年至今（2023年）的相关期刊，关键词为：“肥胖”、“瘦素”、“2型糖尿病”、“动脉粥样硬化”、“心血管和脑血管疾病”。对报告的结果进行了比较和关联。然后整理这些信息以撰写本综述。报告显示，在人类肥胖中，高瘦素血症可诱发高血糖，进而引发高胆固醇血症。一段时间内持续的高胆固醇血症可能会导致血管动脉粥样硬化。因此，肥胖被认为是引发高血糖、高胆固醇血症和血管动脉粥样硬化爆发的一个模板，或者换句话说，从长远来看，肥胖会引发动脉粥样硬化及其相关疾病，如心脏病发作和中风。文献调查表明，人类肥胖的合并症主要始于瘦素和胰岛素抵抗，然后随着代谢紊乱而加剧，最终导致心脏病发作和中风的发病机制。与动脉粥样硬化相关的心血管和脑血管事件是肥胖受试者的独立风险，尤其是在持续性肥胖的情况下。
