一种新型合成佐剂增强树突状细胞功能。
A novel synthetic adjuvant enhances dendritic cell function.
机构信息
School of Molecular and Microbial Sciences (SMMS), The University of Queensland, St Lucia, Queensland, Australia.
出版信息
Immunology. 2009 Sep;128(1 Suppl):e582-8. doi: 10.1111/j.1365-2567.2008.03038.x. Epub 2008 Dec 26.
Abstract
The lipid core peptide (LCP) is a novel, synthetic, self-adjuvanted vaccine delivery system that neatly incorporates the adjuvant, carrier and antigenic peptides of a vaccine into a single molecular entity. This system has been previously shown to efficiently deliver vaccines and induce immunity. Because adjuvants target sentinels of the immune response, such as dendritic cells (DCs), that are widely distributed throughout the body to initiate specific immune responses, we investigated the effects of the adjuvant on DCs. Here we show that LCP targets vaccines to DCs and induces their activation.
摘要
脂质核心肽 (LCP) 是一种新型的、合成的、自佐剂疫苗传递系统，它将疫苗的佐剂、载体和抗原肽巧妙地整合到一个单一的分子实体中。该系统以前被证明能够有效地传递疫苗并诱导免疫。因为佐剂靶向免疫反应的哨兵，如树突状细胞 (DCs)，这些细胞广泛分布于全身，以引发特异性免疫反应，所以我们研究了佐剂对 DCs 的影响。在这里，我们表明 LCP 将疫苗靶向 DCs 并诱导其激活。
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