Haarmark Christian, Graff Claus, Andersen Mads P, Hardahl Thomas, Struijk Johannes J, Toft Egon, Xue Joel, Rowlandson Gordon I, Hansen Peter R, Kanters Jørgen K
The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark.
J Electrocardiol. 2010 Jan-Feb;43(1):31-9. doi: 10.1016/j.jelectrocard.2009.08.001.
Reference values for T-wave morphology analysis and evaluation of the relationship with age, sex, and heart rate are lacking in the literature. In this study, we characterized T-wave morphology in a large sample of healthy individuals.
A total of 1081 healthy subjects (83% men; range, 17-81 years) were included. T-wave morphology variables describing the duration, area, slopes, amplitude, and distribution were calculated using 10-second digital electrocardiogram recordings. Multivariate regression was used to test for dependence of T-wave variables with the subject age, sex, and heart rate.
Lead V5 (men vs women) T-wave variables were as follows: amplitude, 444 versus 317 muV; area, 48.4 versus 33.2 ms mV; Tpeak-Tend interval, 94 versus 92 milliseconds; maximal descending slope, -5.15 versus -3.69 muV/ms; skewness, -0.24 versus -0.22; and kurtosis, -0.36 versus -0.35. Tpeak-Tend interval, skewness, and kurtosis were independent of age, sex, and heart rate (r(2) < 0.05), whereas Bazett-corrected QT-interval was more dependent (r(2) = 0.40).
A selection of T-wave morphology variables is found to be clinically independent of age, sex, and heart rate, including Tpeak-Tend interval, skewness, and kurtosis.
文献中缺乏T波形态分析的参考值以及与年龄、性别和心率关系的评估。在本研究中，我们对大量健康个体的T波形态进行了特征描述。
共纳入1081名健康受试者（83%为男性；年龄范围17 - 81岁）。使用10秒数字心电图记录计算描述持续时间、面积、斜率、振幅和分布的T波形态变量。采用多变量回归检验T波变量与受试者年龄、性别和心率的相关性。
V5导联（男性与女性）的T波变量如下：振幅，444 μV对317 μV；面积，48.4 ms mV对33.2 ms mV；T峰 - T末间期，94毫秒对92毫秒；最大下降斜率，-5.15 μV/ms对-3.69 μV/ms；偏度，-0.24对-0.22；峰度，-0.36对-0.35。T峰 - T末间期、偏度和峰度与年龄、性别和心率无关（r² < 0.05），而Bazett校正的QT间期相关性更强（r² = 0.40）。
发现一系列T波形态变量在临床上与年龄、性别和心率无关，包括T峰 - T末间期、偏度和峰度。
