Keynes R D, Greeff N G, Forster I C
Physiological Laboratory, Cambridge, U.K.
Proc R Soc Lond B Biol Sci. 1990 Jun 22;240(1299):411-23. doi: 10.1098/rspb.1990.0045.
A critical study has been made of the characteristics of the kinetic components of the sodium gating current in the squid giant axon, of which not less than five can be resolved. In addition to the principal fast component Ig2, there are two components of appreciable size that relax at an intermediate rate, Ig3 alpha and Ig 3 beta. Ig3 alpha has a fast rise, and is present over the whole range of negative test potentials. Ig3 beta is absent below -40 mV, exhibits a delayed onset and disappears on inactivation of the sodium system. There are also two smaller components, Ig1 and Ig4, with very fast and much slower relaxation time constants, respectively.
对鱿鱼巨轴突中钠门控电流动力学成分的特性进行了批判性研究，其中至少可分辨出五种成分。除了主要的快速成分Ig2外，还有两个大小可观的成分，它们以中等速率弛豫，即Ig3α和Ig3β。Ig3α上升迅速，在整个负测试电位范围内均存在。Ig3β在-40 mV以下不存在，表现出延迟出现，并在钠系统失活时消失。还有两个较小的成分，Ig1和Ig4，其弛豫时间常数分别非常快和非常慢。
