Pearson-Fuhrhop Kristin M, Kleim Jeffrey A, Cramer Steven C
Department of Anatomy & Neurobiology, University of California, Irvine, Orange, USA.
Top Stroke Rehabil. 2009 Jul-Aug;16(4):282-99. doi: 10.1310/tsr1604-282.
Brain plasticity refers to changes in brain function and structure that arise in a number of contexts. One area in which brain plasticity is of considerable interest is recovery from stroke, both spontaneous and treatment-induced. A number of factors influence these poststroke brain events. The current review considers the impact of genetic factors. Polymorphisms in the human genes coding for brain-derived neurotrophic factor (BDNF) and apolipoprotein E (ApoE) have been studied in the context of plasticity and/or stroke recovery and are discussed here in detail. Several other genetic polymorphisms are indirectly involved in stroke recovery through their modulating influences on processes such as depression and pharmacotherapy effects. Finally, new genetic polymorphisms that have not been studied in the context of stroke are proposed as new directions for study. A better understanding of genetic influences on recovery and response to therapy might allow improved treatment after stroke.
脑可塑性是指在多种情况下出现的脑功能和结构变化。脑可塑性备受关注的一个领域是中风后的恢复，包括自发恢复和治疗诱导的恢复。许多因素影响这些中风后脑事件。本综述考虑了遗传因素的影响。编码脑源性神经营养因子（BDNF）和载脂蛋白E（ApoE）的人类基因中的多态性已在可塑性和/或中风恢复的背景下进行了研究，并在此详细讨论。其他几种基因多态性通过对抑郁症和药物治疗效果等过程的调节作用间接参与中风恢复。最后，提出了尚未在中风背景下研究的新基因多态性作为新的研究方向。更好地理解遗传因素对恢复和治疗反应的影响可能会改善中风后的治疗。
