Laville Rémi, Thomas Olivier P, Berrué Fabrice, Marquez Diana, Vacelet Jean, Amade Philippe
Institut de Chimie de Nice, LCMBA UMR 6001 CNRS, University of Nice-Sophia Antipolis, 28 Avenue de Valrose, Nice, France.
J Nat Prod. 2009 Sep;72(9):1589-94. doi: 10.1021/np900244g.
Seven new guanidine alkaloids (1-7) together with the known batzelladines A, F, H, and L, ptilomycalin A, and fromiamycalin were isolated from the Caribbean marine sponges Monanchora arbuscula and Clathria calla. Molecular structures were assigned on the basis of detailed analysis of 1D and 2D NMR spectra and mass spectrometry data, and bioactivities of the alkaloids were evaluated against human cancer cell lines and malaria protozoa.
从加勒比海海绵Monanchora arbuscula和Clathria calla中分离出七种新的胍生物碱（1-7）以及已知的巴泽拉定A、F、H和L、ptilomycalin A和fromiamycalin。根据一维和二维核磁共振光谱以及质谱数据的详细分析确定了分子结构，并评估了这些生物碱对人类癌细胞系和疟原虫的生物活性。
