Puchois P, Ghalim N, Zylberberg G, Fievet P, Demarquilly C, Fruchart J C
SERLIA, U325 Inserm, Institut Pasteur, Lille, France.
Arch Intern Med. 1990 Aug;150(8):1638-41.
High-density lipoprotein comprises two main types of lipoprotein particles: (1) those that contain apolipoproteins A-I and A-II, designated LpA-I:A-II, and (2) those that contain apolipoprotein A-I but not apolipoprotein A-II, designated LpA-I. Both have been extensively studied and are believed to represent distinct metabolic entities that may confer differing protection against coronary artery disease risk. We have previously suggested that LpA-I might represent the antiatherogenic effect, which has been ascribed mainly to its effect on high-density lipoprotein cholesterol; we set out to investigate, in 344 men, the relation between LpA-I:A-II and LpA-I levels and alcohol consumption. As the alcohol intake rose, LpA-I:A-II levels increased, while LpA-I levels fell. On the assumption that LpA-I is the antiatherogenic fraction of high-density lipoprotein, the putative protective action of alcohol consumption against coronary artery disease should be reconsidered.
（1）含有载脂蛋白A-I和A-II的颗粒，称为LpA-I:A-II；（2）含有载脂蛋白A-I但不含载脂蛋白A-II的颗粒，称为LpA-I。两者都已得到广泛研究，并且被认为代表不同的代谢实体，可能对冠状动脉疾病风险具有不同的保护作用。我们之前曾提出，LpA-I可能代表抗动脉粥样硬化作用，这主要归因于其对高密度脂蛋白胆固醇的影响；我们着手在344名男性中研究LpA-I:A-II和LpA-I水平与饮酒之间的关系。随着酒精摄入量的增加，LpA-I:A-II水平升高，而LpA-I水平下降。假设LpA-I是高密度脂蛋白的抗动脉粥样硬化部分，那么饮酒对冠状动脉疾病的假定保护作用应该重新考虑。
