Department of Dermatology and Allergology, University Hospital Aachen, Aachen.
J Eur Acad Dermatol Venereol. 2010 Apr;24(4):395-402. doi: 10.1111/j.1468-3083.2009.03419.x. Epub 2009 Sep 8.
Soluble immune receptors (SIRs) have been proposed as biomarkers in patients with atopic dermatitis (AD). However, their clinical applicability in affected children has rarely been studied.
To assess the diagnostic usefulness of serum SIRs in childhood AD by correlating the obtained receptor profiles with serological parameters and clinical features such as age, AD phenotype and disease severity.
We investigated 100 children with AD. The sCD14, sCD23, sCD25, sCD30, total IgE (tIgE) and eosinophilic cationic protein (ECP) were determined using sera of all children. The clinical phenotype was classified as extrinsic AD (ADe) or intrinsic AD (ADi) by the presence of allergen-specific IgE antibodies.
A total of 55 male and 45 female children were recruited. The sCD23, sCD25 and sCD30 serum levels revealed significant age-dependency. At a mean SCORAD of 40 (range 8-98), none of the evaluated SIRs was correlated to disease severity. In all, 73% of patients suffered from ADe while 27% showed the ADi phenotype. None of the analysed SIRs differed significantly between ADe and ADi patients, while tIgE and ECP levels were elevated in the ADe subgroup.
The current study provides evidence that sCD23, sCD25 and sCD30 serum levels are highly age-dependent. Serum concentrations of all investigated SIRs did not significantly correlate with disease severity in children with AD and were not differentially expressed in patients of different AD phenotypes. Therefore, we believe that the studied SIRs cannot be regarded as clinically useful biomarkers for the assessment of childhood AD.
可溶性免疫受体（SIRs）已被提议作为特应性皮炎（AD）患者的生物标志物。然而，它们在受影响儿童中的临床适用性很少被研究。
通过将获得的受体谱与血清学参数以及年龄、AD 表型和疾病严重程度等临床特征相关联，评估血清 SIRs 在儿童 AD 中的诊断价值。
我们调查了 100 名患有 AD 的儿童。所有儿童的血清均测定 sCD14、sCD23、sCD25、sCD30、总 IgE（tIgE）和嗜酸性阳离子蛋白（ECP）。通过存在过敏原特异性 IgE 抗体将临床表型分类为特应性 AD（ADe）或内在 AD（ADi）。
共招募了 55 名男性和 45 名女性儿童。sCD23、sCD25 和 sCD30 的血清水平显示出显著的年龄依赖性。在平均 SCORAD 为 40（范围 8-98）时，评估的 SIRs 均与疾病严重程度无关。在所有患者中，73%患有 ADe，而 27%表现出 ADi 表型。分析的 SIRs 在 ADe 和 ADi 患者之间没有显著差异，而 tIgE 和 ECP 水平在 ADe 亚组中升高。
本研究提供的证据表明，sCD23、sCD25 和 sCD30 的血清水平高度依赖于年龄。AD 儿童中所有研究 SIR 的血清浓度与疾病严重程度无显著相关性，且在不同 AD 表型患者中的表达无差异。因此，我们认为研究的 SIRs 不能作为评估儿童 AD 的临床有用的生物标志物。
