Department of Pharmacoeconomics, Medical University of Warsaw, Poland.
Value Health. 2010 Mar-Apr;13(2):289-97. doi: 10.1111/j.1524-4733.2009.00596.x. Epub 2009 Sep 10.
Currently, there is no EQ-5D value set for Poland. The primary objective of this study was to elicit EQ-5D Polish values using the time trade-off (TTO) method.
Face-to-face interviews with visitors of inpatients in eight medical centers in Warsaw, Skierniewice, and Puławy were carried out by trained interviewers. Quota sampling was used to achieve a representative sample of the Polish population with regard to age and sex. Modified protocol from the Measurement and Value of Health study was used. Each respondent ranked 10 health states and valued 4 health states using the visual analog scale and 23 using the TTO. Mean and variance stability tests were performed to determine whether using a larger number of health states per respondent would yield credible results. Modeling included random effects and random parameters models.
Between February and May 2008, 321 interviews were performed. Modeling based on 6777 valuations resulted in an additive model with all coefficients statistically significant, R(2) equal to 0.45, and value -0.523 for the worst possible health state. Means and variance did not differ significantly for states valued in the middle and at the end of the TTO exercise.
This is the first EQ-5D value set based on TTO in Central and Eastern Europe so far. Because the values differ considerably from those elicited in Western European countries, its use should be recommended for studies in Poland. Increasing the number of health states that each respondent is asked to value using TTO seems feasible and justifiable.
目前波兰尚无 EQ-5D 值集。本研究的主要目的是使用时间权衡 (TTO) 法得出 EQ-5D 波兰值。
在华沙、斯凯尔涅维采和普乌瓦瓦的 8 家医疗中心，由经过培训的访视员对住院病人的来访者进行面对面访谈。使用配额抽样以确保在年龄和性别方面具有代表性的波兰人群样本。使用健康衡量和价值研究的修改方案。每位受访者对 10 种健康状态进行排序，并使用视觉模拟量表对 4 种健康状态和 TTO 对 23 种健康状态进行赋值。进行均值和方差稳定性检验以确定每位受访者使用更多的健康状态是否会产生可信的结果。模型包括随机效应和随机参数模型。
在 2008 年 2 月至 5 月期间进行了 321 次访谈。基于 6777 次赋值的建模得出一个加性模型，所有系数均具有统计学意义，R(2) 等于 0.45，最差健康状态的赋值为-0.523。在 TTO 练习的中间和结束时，赋值的状态的均值和方差没有显著差异。
这是迄今为止在中东欧基于 TTO 的第一个 EQ-5D 值集。由于与西欧国家得出的值差异很大，因此建议在波兰的研究中使用。增加每位受访者使用 TTO 评估的健康状态数量似乎是可行和合理的。
