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聚乙二醇干扰素 α-2b 和利巴韦林治疗慢性丙型肝炎期间 1 型糖尿病和格雷夫斯病的双重发作。

Dual onset of type 1 diabetes mellitus and Graves' disease during treatment with pegylated interferon alpha-2b and ribavirin for chronic hepatitis C.

机构信息

Department of Endocrinology and Metabolism, Chukyo Hospital, Nagoya 457-8510, Japan.

出版信息

Diabetes Res Clin Pract. 2009 Nov;86(2):e19-21. doi: 10.1016/j.diabres.2009.08.009. Epub 2009 Sep 9.

DOI:10.1016/j.diabres.2009.08.009
PMID:19744739
Abstract

Currently, a combination therapy of pegylated (PEG) interferon (IFN) alpha-2b and ribavirin are being widely used for the treatment of chronic hepatitis C (CHC). We describe here a case of dual onset of type 1 DM accompanied by ketoacidosis, and Graves' disease during the combination therapy via the autoimmune process.

摘要

目前，聚乙二醇（PEG）干扰素（IFN）α-2b 和利巴韦林联合治疗被广泛用于慢性丙型肝炎（CHC）的治疗。我们在此描述了一例在联合治疗过程中通过自身免疫过程发生的 1 型糖尿病伴酮症酸中毒和格雷夫斯病双重发作的病例。

相似文献

1
Dual onset of type 1 diabetes mellitus and Graves' disease during treatment with pegylated interferon alpha-2b and ribavirin for chronic hepatitis C.聚乙二醇干扰素 α-2b 和利巴韦林治疗慢性丙型肝炎期间 1 型糖尿病和格雷夫斯病的双重发作。
Diabetes Res Clin Pract. 2009 Nov;86(2):e19-21. doi: 10.1016/j.diabres.2009.08.009. Epub 2009 Sep 9.
2
A case of type 1 diabetes onset and recurrence of Graves' disease during pegylated interferon-α plus ribavirin treatment for chronic hepatitis C.1例慢性丙型肝炎患者在聚乙二醇化干扰素-α联合利巴韦林治疗期间发生1型糖尿病并复发格雷夫斯病。
Intern Med. 2010;49(18):1987-90. doi: 10.2169/internalmedicine.49.3831. Epub 2010 Sep 15.
3
[Type 1 diabetes developing during alpha-interferon therapy: report of two cases].α干扰素治疗期间发生的1型糖尿病：两例报告
Endocrinol Nutr. 2010 Oct;57(8):393-5. doi: 10.1016/j.endonu.2010.03.016. Epub 2010 May 11.
4
[Occurrence of diabetic ketoacidosis and autoimmune thyroiditis in a patient treated with pegylated interferon-alpha 2b and ribavirin for chronic hepatitis C].[聚乙二醇化干扰素-α2b和利巴韦林治疗慢性丙型肝炎患者中糖尿病酮症酸中毒和自身免疫性甲状腺炎的发生情况]
Korean J Hepatol. 2010 Jun;16(2):187-91. doi: 10.3350/kjhep.2010.16.2.187.
5
Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C.慢性丙型肝炎患者接受聚乙二醇干扰素和利巴韦林抗病毒治疗期间的甲状腺功能及超声形态学变化
J Viral Hepat. 2009 Mar;16(3):168-77. doi: 10.1111/j.1365-2893.2008.01059.x. Epub 2008 Oct 17.
6
Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C.聚乙二醇干扰素和利巴韦林治疗慢性丙型肝炎期间发生眼肌型重症肌无力
Korean J Hepatol. 2009 Jun;15(2):209-15. doi: 10.3350/kjhep.2009.15.2.209.
7
Is combination therapy interferon and ribavirin in patients with chronic hepatitis C infection toxic for eyes?慢性丙型肝炎感染患者的干扰素和利巴韦林联合治疗对眼睛有毒性吗？
J Ocul Pharmacol Ther. 2013 Apr;29(3):345-8. doi: 10.1089/jop.2012.0169. Epub 2012 Oct 31.
8
[Pegylated-interferon-induced diabetes mellitus type 1 in two patients with chronic hepatitis C].[聚乙二醇干扰素诱发两名慢性丙型肝炎患者患1型糖尿病]
Gastroenterol Hepatol. 2004 Feb;27(2):69. doi: 10.1016/s0210-5705(03)79089-x.
9
Cutaneous sarcoidosis associated with pegylated interferon alfa and ribavirin therapy in a patient with chronic hepatitis C.慢性丙型肝炎患者接受聚乙二醇化干扰素α和利巴韦林治疗后出现的皮肤结节病
J Am Acad Dermatol. 2004 Apr;50(4):649-50. doi: 10.1016/j.jaad.2003.06.013.
10
Alopecia universalis: a rare side effect seen on chronic hepatitis C treatment with peg-IFN and ribavirin.全秃：聚乙二醇干扰素和利巴韦林治疗慢性丙型肝炎时出现的一种罕见副作用。
Eur J Dermatol. 2006 Sep-Oct;16(5):579-80.

引用本文的文献

1
Interferon therapy in hepatitis C leading to chronic type 1 diabetes.丙型肝炎的干扰素治疗导致慢性1型糖尿病。
World J Gastroenterol. 2015 Jan 7;21(1):233-9. doi: 10.3748/wjg.v21.i1.233.
2
Hepatitis C virus infection and type 1 and type 2 diabetes mellitus.丙型肝炎病毒感染与 1 型和 2 型糖尿病。
World J Diabetes. 2014 Oct 15;5(5):586-600. doi: 10.4239/wjd.v5.i5.586.
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The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease.Ⅰ型和Ⅲ型干扰素对肾上腺皮质细胞的影响及其对自身免疫性艾迪生病的可能意义。
Clin Exp Immunol. 2014 Jun;176(3):351-62. doi: 10.1111/cei.12291.
4
Type 1 Diabetes Mellitus Associated with Pegylated Interferon-α Plus Ribavirin Treatment for Chronic Hepatitis C: Case Report and Literature Review.聚乙二醇化干扰素-α联合利巴韦林治疗慢性丙型肝炎相关的1型糖尿病：病例报告及文献综述
Clin Med Insights Endocrinol Diabetes. 2011;4:39-45. doi: 10.4137/CMED.S7815. Epub 2011 Aug 23.
5
Type I interferon in organ-targeted autoimmune and inflammatory diseases.I 型干扰素在器官靶向性自身免疫和炎症性疾病中的作用。
Arthritis Res Ther. 2010;12 Suppl 1(Suppl 1):S5. doi: 10.1186/ar2886. Epub 2010 Aug 25.