Inomata H, Sakamoto T
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Curr Eye Res. 1990;9 Suppl:35-40. doi: 10.3109/02713689008999417.
We studied Vogt-Koyanagi-Harada disease (VKH) with sunset sky fundus using histopathology and immunohistochemical methods. The materials examined were 4 eyes obtained at autopsy on two patients with VKH. The first patient died 32 months after the onset of VKH, and the other 7 years after onset. Histopathology of the eyes showed scattering infiltration of lymphocytes in the thickened choroid with a remarkable disappearance of choroidal melanocytes. T and B lymphocytes were identified by immunohistochemistry, using monoclonal antibodies. Approximately 70% of the lymphocytes were T cells. In the case 1 patient, the ratio of CD4+ to CD8+ T cells was 2 to 3. Thus, the evidence of T and B lymphocytes in these uveal tissues indicates that the inflammation remained active even at the convalescent stage.
我们采用组织病理学和免疫组化方法研究了伴有晚霞状眼底的伏格特-小柳-原田病（VKH）。所检查的材料为两名VKH患者尸检时获取的4只眼睛。第一名患者在VKH发病32个月后死亡，另一名在发病7年后死亡。眼部组织病理学显示，增厚的脉络膜中有淋巴细胞散在浸润，脉络膜黑素细胞明显消失。使用单克隆抗体通过免疫组化鉴定出T淋巴细胞和B淋巴细胞。约70%的淋巴细胞为T细胞。在病例1患者中，CD4 + T细胞与CD8 + T细胞的比例为2比3。因此，这些葡萄膜组织中存在T淋巴细胞和B淋巴细胞的证据表明，即使在恢复期炎症仍处于活跃状态。
