Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Retina. 2014 Apr;34(4):775-80. doi: 10.1097/IAE.0b013e3182a6b3f6.
To evaluate the subfoveal choroidal thickness (SCT) at the convalescent stage of Vogt-Koyanagi-Harada disease and to investigate the correlations among SCT, the presence of the sunset glow fundus, and size of the peripapillary atrophy (PPA).
The medical records of consecutive patients with Vogt-Koyanagi-Harada disease without active intraocular inflammation were reviewed, and one eye was randomly chosen for analyses. The disease duration was more than 3 years. Enhanced depth imaging optical coherence tomography was performed to measure SCT. The area of PPA was measured using the PDT/MPS software. Sunset glow fundi were classified into two groups according to the degree of depigmentation.
Nineteen eyes with Vogt-Koyanagi-Harada disease were studied. The mean SCT of 12 eyes with severe sunset glow fundus was 144 ± 72 μm which was thinner than that of the 7 eyes with no or mild depigmentation (P = 0.0057). The SCT was inversely correlated with the disease duration (P = 0.048) and the PPA area (P = 0.0002). The PPA area was positively correlated with the disease duration (P = 0.007).
The thinner choroid and larger PPA areas were correlated with the degree of depigmentation or disease duration and might be caused by latent choroidal inflammation in the convalescent stage of Vogt-Koyanagi-Harada disease.
评估 Vogt-小柳-原田病（VKH）恢复期的黄斑中心凹下脉络膜厚度（SCT），并探讨 SCT 与晚霞征、视盘周围萎缩（PPA）大小的相关性。
回顾性分析了连续无活动性眼内炎症的 VKH 患者的病历，并随机选择一只眼进行分析。病程超过 3 年。采用增强深度成像光相干断层扫描测量 SCT。使用 PDT/MPS 软件测量 PPA 的面积。根据脱色素程度将晚霞征分为两组。
19 只 VKH 眼纳入研究。12 只重度晚霞征眼的平均 SCT 为 144±72μm，明显薄于 7 只无或轻度脱色素眼（P=0.0057）。SCT 与病程（P=0.048）和 PPA 面积（P=0.0002）呈负相关。PPA 面积与病程呈正相关（P=0.007）。
脉络膜变薄和 PPA 面积增大与脱色素程度或病程有关，可能是 VKH 恢复期潜在脉络膜炎症所致。
